Wang Xinyuan, Tian Hao, Pan Wen, Du Binhong, Chen Zhen, Zhang Rongzhi, Zhou Ping
Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School and Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, China.
School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Nanomedicine (Lond). 2025 Feb;20(3):319-328. doi: 10.1080/17435889.2024.2443378. Epub 2024 Dec 24.
The maturation of cardiomyocytes (CMs) plays key roles in regenerative medicine and the treatment of cardiovascular diseases via stem cell-derived CMs. Carbon dots (CDs) have good biocompatibility, optical properties, and electrophysical properties and have been widely applied in bioimaging, biosensors, and biotherapy. In this review, we comprehensively summarize recent advances in promoting the maturation of CMs, mainly human pluripotent stem cell-derived CMs, and related regenerative medicine. Moreover, we explore the innovative application of CDs to enhance the maturation of these CMs. Finally, we look forward to the future design and application of CDs in the maturation of CMs in terms of cell therapies.
心肌细胞（CMs）的成熟在再生医学以及通过干细胞衍生的心肌细胞治疗心血管疾病中起着关键作用。碳点（CDs）具有良好的生物相容性、光学性质和电物理性质，已广泛应用于生物成像、生物传感器和生物治疗。在本综述中，我们全面总结了促进心肌细胞成熟（主要是人类多能干细胞衍生的心肌细胞）及相关再生医学的最新进展。此外，我们探讨了碳点在促进这些心肌细胞成熟方面的创新应用。最后，我们从细胞治疗的角度展望了碳点在心肌细胞成熟方面未来的设计与应用。
