Yang Caixia, Lin Gan, Zhu Congqing, Pang Xin, Zhang Yang, Wang Xiaoyong, Li Xianglin, Wang Bin, Xia Haiping, Liu Gang
Medical Imaging Research Institute, Binzhou Medical University, Yantai, Shandong 264003, China.
J Mater Chem B. 2018 May 7;6(17):2528-2535. doi: 10.1039/c7tb02145c. Epub 2017 Oct 5.
In this study, metalla-aromatic agents (MA) and a cluster of superparamagnetic iron oxide nanoparticles (SPIOs) were loaded inside a micellar carrier (Alkyl-PEI2k-PEG), resulting in MA/SPIOs@Alkyl-PEI2k-PEG nanoparticles (MASAs). The prepared MASAs with a photothermal transduction efficiency of 26.6% were also demonstrated as a potential photodynamic sensitizer to generate ROS effectively. Under the guidance of MRI/photoacoustic imaging, combined photothermal and photodynamic therapy achieved a synergistic anti-tumor effect, significantly improving the therapeutic efficacy of MASAs both in vitro and in vivo. This work shows that the developed MASAs are a potential theranostic agent for dual-modal imaging-guided cancer phototherapy.
在本研究中，金属芳香剂（MA）和一组超顺磁性氧化铁纳米颗粒（SPIOs）被负载在胶束载体（烷基-PEI2k-PEG）内，从而得到MA/SPIOs@烷基-PEI2k-PEG纳米颗粒（MASAs）。所制备的光热转换效率为26.6%的MASAs还被证明是一种能够有效产生活性氧的潜在光动力敏化剂。在磁共振成像/光声成像的引导下，光热和光动力联合疗法实现了协同抗肿瘤效应，显著提高了MASAs在体外和体内的治疗效果。这项工作表明，所开发的MASAs是一种用于双模态成像引导癌症光疗的潜在诊疗试剂。
