Luo Mingfang, Lv Yijie, Luo Xunrong, Ren Qingfa, Sun Zhenbo, Li Tianping, Wang Ailing, Liu Yan, Yang Caixia, Li Xianglin
School of Medical Imaging, Binzhou Medical University, Yantai, China.
Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China.
Front Bioeng Biotechnol. 2022 Feb 21;10:799610. doi: 10.3389/fbioe.2022.799610. eCollection 2022.
With the development of nanotechnology, a theranostics nanoplatform can have broad applications in multimodal image-guided combination treatment in cancer precision medicine. To overcome the limitations of a single diagnostic imaging mode and a single chemotherapeutic approach, we intend to combat tumor growth and provide therapeutic interventions by integrating multimodal imaging capabilities and effective combination therapies on an advanced platform. So, we have constructed IO@MnO@DOX (IMD) hybrid nanoparticles composed of superparamagnetic iron oxide (IO), manganese dioxide (MnO), and doxorubicin (DOX). The nano-platform could achieve efficient T2-T1 magnetic resonance (MR) imaging, switchable photoacoustic (PA) imaging, and tumor microenvironment (TME)-responsive DOX release and achieve enhanced synergism of magnetic hyperthermia and chemotherapy with PA/MR bimodal imaging. The results show that IMD has excellent heating properties when exposed to an alternating magnetic field (AMF). Therefore, it can be used as an inducer for tumor synergism therapy with chemotherapy and hyperthermia. In the TME, the IMD nanoparticle was degraded, accompanied by DOX release. Moreover, experimental results show that the smart nanoparticles had excellent T2-T1 MR and PA imaging capabilities and an excellent synergistic effect of magnetic hyperthermia and chemotherapy. IMD nanoparticles could significantly inhibit tumor growth in tumor-bearing mice with negligible side effects. In conclusion, smart IMD nanoparticles have the potential for tumor diagnosis and growth inhibition as integrated diagnostic nanoprobes.
随着纳米技术的发展，一种诊疗纳米平台在癌症精准医学的多模态图像引导联合治疗中具有广泛应用。为克服单一诊断成像模式和单一化疗方法的局限性，我们打算通过在一个先进平台上整合多模态成像能力和有效的联合疗法来对抗肿瘤生长并提供治疗干预。因此，我们构建了由超顺磁性氧化铁（IO）、二氧化锰（MnO）和阿霉素（DOX）组成的IO@MnO@DOX（IMD）复合纳米颗粒。该纳米平台可实现高效的T2-T1磁共振（MR）成像、可切换的光声（PA）成像以及肿瘤微环境（TME）响应性DOX释放，并通过PA/MR双模态成像实现磁热疗与化疗的增强协同作用。结果表明，IMD在交变磁场（AMF）作用下具有优异的加热性能。因此，它可作为化疗和热疗联合肿瘤协同治疗的诱导剂。在TME中，IMD纳米颗粒降解，同时伴有DOX释放。此外，实验结果表明，这种智能纳米颗粒具有优异的T2-T1 MR和PA成像能力以及磁热疗与化疗的优异协同效应。IMD纳米颗粒可显著抑制荷瘤小鼠的肿瘤生长，且副作用可忽略不计。总之，智能IMD纳米颗粒作为集成诊断纳米探针具有肿瘤诊断和生长抑制的潜力。
