Ministry Key Laboratory of Oil and Gas Fine Chemicals, College of Chemistry and Chemical Engineering, Xinjiang University , Urumqi 830046, China.
Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
ACS Nano. 2017 Sep 26;11(9):9239-9248. doi: 10.1021/acsnano.7b04461. Epub 2017 Sep 5.
Imaging-guided photothermal therapy (PTT) by combination of imaging and PTT has been emerging as a promising therapeutic method for precision therapy. However, the development of multicomponent nanoplatforms with stable structures for both PTT and multiple-model imaging remains a great challenge. Herein, we synthesized monodisperse Au-FeC Janus nanoparticles (JNPs) of 12 nm, which are multifunctional entities for cancer theranostics. Due to the broad absorption in the near-infrared range, Au-FeC JNPs showed a significant photothermal effect with a 30.2% calculated photothermal transduction efficiency under 808 nm laser irradiation in vitro. Owing to their excellent optical and magnetic properties, Au-FeC JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/multispectral photoacoustic tomography (MSOT)/computed tomography (CT) both in vitro and in vivo. We found that Au-FeC JNPs conjugated with the affibody (Au-FeC-Z) have more accumulation and deeper penetration in tumor sites than nontargeting JNPs (Au-FeC-PEG) in vivo. Meanwhile, our results verified that Au-FeC-Z JNPs can selectively target tumor cells with low cytotoxicity and ablate tumor tissues effectively in a mouse model. In summary, monodisperse Au-FeC JNPs, used as a multifunctional nanoplatform, allow the combination of multiple-model imaging techniques and high therapeutic efficacy and have great potential for precision theranostic nanomedicines.
基于成像和光热治疗（PTT）相结合的影像引导光热治疗（PTT）已成为精准治疗的一种很有前途的治疗方法。然而，开发具有稳定结构的多功能纳米平台，用于 PTT 和多种模式成像，仍然是一个巨大的挑战。在此，我们合成了 12nm 的单分散 Au-FeC 双金属 Janus 纳米粒子（JNPs），这是一种多功能癌症治疗和诊断的实体。由于在近红外区域的宽吸收，Au-FeC JNPs 在体外 808nm 激光照射下显示出显著的光热效应，计算的光热转换效率为 30.2%。由于其出色的光学和磁学性质，Au-FeC JNPs 被证明是用于磁共振成像（MRI）/多光谱光声断层扫描（MSOT）/计算机断层扫描（CT）的三模态成像的优势试剂，无论是在体外还是体内。我们发现，Au-FeC JNPs 与亲和体（Au-FeC-Z）偶联后，在体内比非靶向 JNPs（Au-FeC-PEG）在肿瘤部位有更多的积累和更深的穿透。同时，我们的结果证实，Au-FeC-Z JNPs 可以选择性地靶向肿瘤细胞，具有低细胞毒性，并能有效地在小鼠模型中消融肿瘤组织。总之，单分散的 Au-FeC JNPs 作为一种多功能纳米平台，允许多种模式成像技术的结合和高治疗效果，并为精准治疗的纳米医学提供了巨大的潜力。
