Jiang Meijuan, Kwok Ryan T K, Li Xuesong, Gui Chen, Lam Jacky W Y, Qu Jianan, Tang Ben Zhong
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
J Mater Chem B. 2018 May 7;6(17):2557-2565. doi: 10.1039/c7tb02609a. Epub 2017 Nov 10.
Two-photon excited photodynamic therapy (TP-PDT) is not only able to offer deeper penetration depth but also much more precise 3D treatment than traditional one-photon excited PDT. However, the achievement of TP-PDT requires photosensitizers with large two-photon absorption cross sections, efficient generation of reactive oxygen species, and bright two-photon fluorescence. In this work, we present a simple AIE luminogen (AIEgen), IQ-TPA, with mitochondrial targeting and susceptible two-photon excitation for image-guided photodynamic therapy in cancer cells. This feasibility of utilizing small molecular multifunctional AIEgens for TP-PDT was demonstrated together with the merits of tiny size, good cell permeability, low dark cytotoxicity and easy synthesis, showing great potential for the development of future theranostic systems.
双光子激发光动力疗法（TP-PDT）不仅能够提供比传统单光子激发光动力疗法更深的穿透深度，而且能实现更精确的三维治疗。然而，实现TP-PDT需要具有大二光子吸收截面、高效产生活性氧以及明亮双光子荧光的光敏剂。在这项工作中，我们展示了一种简单的聚集诱导发光 luminogen（AIEgen），IQ-TPA，它具有线粒体靶向性和易受双光子激发的特性，可用于癌细胞的图像引导光动力治疗。利用小分子多功能AIEgens进行TP-PDT的可行性得到了证明，同时还具有尺寸小、细胞渗透性好、暗毒性低和易于合成等优点，显示出未来诊疗系统发展的巨大潜力。
