Ingle Jaypalsing, Basu Sudipta
Discipline of Chemistry, Indian Institute of Technology (IIT) Gandhinagar, Palaj, Gujarat 382355, India.
ACS Omega. 2023 Mar 1;8(10):8925-8935. doi: 10.1021/acsomega.3c00203. eCollection 2023 Mar 14.
In recent years, mitochondrion (powerhouse of the cells) gained lots of interest as one of the unorthodox targets for futuristic cancer therapy. As a result, novel small molecules were developed to damage and image mitochondria in cancer models. In this context, aggregation-induced emission probes (AIEgens) received immense attention due to their applications in mitochondria-targeted biosensing, imaging, and biomedical theranostics. On the other hand, phototherapy (photodynamic and photothermal) has emerged as a powerful alternative to manage cancer due to its less invasive nature. However, merging these two areas to engineer mitochondria-targeted phototherapeutic probes for cancer diagnosis and treatment has remained a major challenge. In this mini-review, we will outline the development of novel mitochondria-targeted small molecule AIEgens as imaging agents and photosensitizers for photodynamic therapy along with dual photodymanic-phototheramal therapy and chemo-photodynamic therapy. We will also highlight the current challenges in developing mitochondria-targeted photothermal therapy probes for future biomedical theranostic applications to manage cancer.
近年来，线粒体（细胞的动力源）作为未来癌症治疗的非传统靶点之一备受关注。因此，人们开发了新型小分子来损伤癌症模型中的线粒体并对其成像。在此背景下，聚集诱导发光探针（AIEgens）因其在线粒体靶向生物传感、成像及生物医学诊疗中的应用而受到广泛关注。另一方面，光疗法（光动力和光热疗法）因其侵入性较小，已成为治疗癌症的一种有力替代方法。然而，将这两个领域结合起来设计用于癌症诊断和治疗的线粒体靶向光疗探针仍然是一项重大挑战。在这篇小型综述中，我们将概述新型线粒体靶向小分子AIEgens作为光动力疗法成像剂和光敏剂以及光动力 - 光热联合疗法和化学 - 光动力疗法的发展情况。我们还将强调在开发用于未来生物医学诊疗应用以治疗癌症的线粒体靶向光热疗法探针方面当前面临的挑战。
