Ma Dik-Lung, Wu Chun, Tang Wei, Gupta Ashwin-Rajesh, Lee Fu-Wa, Li Guodong, Leung Chung-Hang
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
J Mater Chem B. 2018 Jan 28;6(4):537-544. doi: 10.1039/c7tb02859h. Epub 2017 Dec 20.
Phosphorescent iridium(iii) complexes have gained increasing attention in biological applications owing to their excellent photophysical properties and efficient transportation into live cells. Their advantageous properties make them useful tools for enabling the intracellular detection of many different species for biological and medical applications. In this review, we summarize recent studies on the combination of iridium(iii) complexes and nanomaterials for intracellular sensing, drug delivery and photodynamic therapy. Various mechanisms and application modes are described and compared, and the outlook and future directions of this field are discussed as well.
由于具有优异的光物理性质以及能够高效转运进入活细胞，磷光铱（III）配合物在生物应用中受到越来越多的关注。其有利特性使其成为用于生物和医学应用中对多种不同物种进行细胞内检测的有用工具。在本综述中，我们总结了铱（III）配合物与纳米材料相结合用于细胞内传感、药物递送和光动力疗法的近期研究。描述并比较了各种机制和应用模式，还讨论了该领域的前景和未来方向。
