Zhang Jun, Huang Yike, Yue Dan, Cui Yuanjing, Yang Yu, Qian Guodong
State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
J Mater Chem B. 2018 Aug 21;6(31):5174-5180. doi: 10.1039/c8tb01592a. Epub 2018 Jul 31.
A water stable metal-organic framework, ZJU-108, was designed and successfully synthesized as a luminescent turn-up sensor, and it can discriminate tryptophan from other natural amino acids in aqueous solution. Because of the apparent lower singlet level of tryptophan compared with other amino acids, the singlet-singlet Förster energy transfer mechanism was applied to design a luminescent sensor. As a result, a selective MOF sensor for tryptophan was realized by choosing the ligand with the appropriate singlet energy level. As expected, ZJU-108 shows an excellent luminescence enhancement response to tryptophan over other natural amino acids with a detection limit of 42.9 nM. This work presents a new insight for designing turn-up MOF sensors and demonstrates the potential of ZJU-108 as a luminescent probe for the detection of tryptophan.
一种水稳定的金属有机框架材料ZJU - 108被设计并成功合成，作为一种荧光增强型传感器，它能够在水溶液中区分色氨酸与其他天然氨基酸。由于色氨酸的单重态能级明显低于其他氨基酸，因此采用单重态-单重态Förster能量转移机制来设计荧光传感器。结果，通过选择具有合适单重态能级的配体，实现了一种对色氨酸具有选择性的金属有机框架传感器。正如预期的那样，ZJU - 108对色氨酸表现出优于其他天然氨基酸的出色荧光增强响应，检测限为42.9 nM。这项工作为设计荧光增强型金属有机框架传感器提供了新的见解，并展示了ZJU - 108作为检测色氨酸的荧光探针的潜力。
