Li Hui, Ren Jie, Xu Xiufang, Ning Liangmin, Tong Ruoyan, Song Yao, Liao Shengyun, Gu Wen, Liu Xin
Collaborative Innovation Center of Chemical Science and Engineering, Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai University, Tianjin 300071, China.
Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, No. 391 Binshuixi Road, Tianjin 300384, China.
Analyst. 2019 Aug 7;144(15):4513-4519. doi: 10.1039/c9an00718k. Epub 2019 Jun 26.
Pyrophosphate (PPi) is a significant biological anion, and its abnormal level in the human body is regarded as a signal of some diseases. Herein, we developed a method for the detection of PPi using a luminescent ZTMOF-1 via the luminescence turn-on effect. PPi formed hydrogen bonds with the phenyl and pyridine rings in the framework, and ZTMOF-1 could discriminately detect PPi among other phosphorus oxides in both an aqueous solution and a physiological environment. In addition, to the best of our knowledge, this is the first report on the use of a regenerable MOF-based luminescent sensor for the detection of PPi. Moreover, ZTMOF-1 showed an excellent luminescence quenching response to nitrofurantoin (NFT) over other drugs with the detection limit of 0.175 μM. This study presents a dual-responsive regenerable luminescent probe for the detection of PPi and NFT.
焦磷酸（PPi）是一种重要的生物阴离子，其在人体内的异常水平被视为某些疾病的信号。在此，我们开发了一种通过发光开启效应利用发光的ZTMOF-1检测PPi的方法。PPi与骨架中的苯基和吡啶环形成氢键，并且ZTMOF-1能够在水溶液和生理环境中在其他磷氧化物中选择性地检测PPi。此外，据我们所知，这是首次关于使用可再生的基于金属有机框架的发光传感器检测PPi的报道。此外，ZTMOF-1对呋喃妥因（NFT）表现出优于其他药物的出色发光猝灭响应，检测限为0.175μM。本研究提出了一种用于检测PPi和NFT的双响应可再生发光探针。
