Liu Yao, Wang Xuejun, Ouyang Boshu, Liu Xianping, Du Yang, Cai Xuzheng, Guo Huishu, Pang Zhiqing, Yang Wuli, Shen Shun
Central laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian 116021, China.
J Mater Chem B. 2018 Nov 21;6(43):7033-7041. doi: 10.1039/c8tb02143k. Epub 2018 Oct 18.
Polypyrrole nanoparticles (PPy NPs) have been extensively studied for photothermal therapy (PTT) of tumors because they can generate heat upon near-infrared (NIR) irradiation. Developing non-toxic, self-targeting and long-circulating PPy biomaterials to maximize photothermal effects remains challenging. Here, we show that PPy NPs camouflaged with fusing red blood cells (RBC) and platelet (PLT) membranes can kill tumor cells under direct near infrared irradiation (NIR). The resulting RBC-PLT hybrid membrane-coated PPy NPs (PPy@[R-P] NPs) possess characteristics of both RBC and PLT, exhibiting long circulation times and self-targeting properties. After administration of PPy@[R-P] NPs via tail vein, tumor vessels were injured by photothermal stimulation under NIR laser exposure, which induced a large amount of microthrombosis. Due to the existence of PLT membranes, a large number of PPy@[R-P] NPs were successfully recruited to the microthrombosis sites. As a result, the distribution of nanomaterials in the tumor tissues was improved, and excellent photothermal treatment was achieved. The resulting PPy@[R-P] NPs may contribute to anti-tumor PTT.
聚吡咯纳米颗粒（PPy NPs）因其在近红外（NIR）照射下能产生热量，已被广泛研究用于肿瘤的光热治疗（PTT）。开发无毒、自靶向且长循环的PPy生物材料以最大化光热效应仍然具有挑战性。在此，我们表明用融合红细胞（RBC）和血小板（PLT）膜伪装的PPy NPs在直接近红外照射（NIR）下可杀死肿瘤细胞。所得的红细胞-血小板混合膜包被的PPy NPs（PPy@[R-P] NPs）兼具RBC和PLT的特性，表现出长循环时间和自靶向特性。通过尾静脉注射PPy@[R-P] NPs后，在近红外激光照射下，肿瘤血管因光热刺激而受损，从而诱导大量微血栓形成。由于PLT膜的存在，大量PPy@[R-P] NPs成功募集到微血栓形成部位。结果，纳米材料在肿瘤组织中的分布得到改善，并实现了优异的光热治疗效果。所得的PPy@[R-P] NPs可能有助于抗肿瘤PTT。
