Liu Haiyang, Liu Tianqi, Li Jia, Zhang Youming, Li Jiahua, Song Jun, Qu Junle, Wong Wai-Yeung
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China.
J Mater Chem B. 2018 Sep 14;6(34):5435-5442. doi: 10.1039/c8tb01743c. Epub 2018 Aug 16.
A simple Schiff base fluorescent sensor (BDNOL) was synthesized from the reaction of picolinohydrazide and 4-(diethylamino)salicylaldehyde, and developed for selective detection of Al and Zn. This non-fluorescent sensor displayed obvious fluorescence enhancement after binding to Al/Zn ions with high sensitivity and selectivity, accompanied by obvious fluorescence emission enhancement (504 nm for Al and 575 nm for Zn). The detection limits were found to be 8.30 × 10 M for Al and 1.24 × 10 M for Zn. The binding mechanisms between BDNOL and Al/Zn ions were supported by H NMR and HR-MS analysis, and a density functional theory (DFT) study. The sensing behavior was also studied with molecular logic functions of OR, AND, and NOT gates. Furthermore, the fluorescent sensor was successfully used to recognize Al and Zn in living cells, suggesting that this simple biosensor has great potential in biological imaging applications.
一种简单的席夫碱荧光传感器（BDNOL）由吡啶甲酰肼与4-（二乙氨基）水杨醛反应合成，并用于选择性检测铝和锌。这种非荧光传感器在与铝/锌离子结合后表现出明显的荧光增强，具有高灵敏度和选择性，同时伴随着明显的荧光发射增强（铝为504nm，锌为575nm）。发现铝的检测限为8.30×10⁻⁸M，锌的检测限为1.24×10⁻⁸M。¹H NMR、高分辨质谱（HR-MS）分析以及密度泛函理论（DFT）研究支持了BDNOL与铝/锌离子之间的结合机制。还利用或、与、非门的分子逻辑功能研究了传感行为。此外，该荧光传感器成功用于识别活细胞中的铝和锌，表明这种简单的生物传感器在生物成像应用中具有巨大潜力。
