用于提高药物疗效的还原敏感型细胞穿透纳米纤维的设计与制备
Design and fabrication of reduction-sensitive cell penetrating nanofibers for enhanced drug efficacy.
作者信息
Yang Su, Xu Dawei, Dong He
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
出版信息
J Mater Chem B. 2018 Nov 28;6(44):7179-7184. doi: 10.1039/c8tb00728d. Epub 2018 May 2.
PMID:32254632
Abstract
This work demonstrates a modular design strategy based on the supramolecular assembly of multidomain peptides to fabricate reduction-responsive cell penetrating nanofibers (CPNs), which hold great promise for selective targeting of cancer therapeutics to tumor cells.
摘要
这项工作展示了一种基于多结构域肽超分子组装的模块化设计策略，用于制造还原响应性细胞穿透纳米纤维（CPN），这对于将癌症治疗剂选择性靶向肿瘤细胞具有巨大潜力。
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