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用于提高药物疗效的还原敏感型细胞穿透纳米纤维的设计与制备

Design and fabrication of reduction-sensitive cell penetrating nanofibers for enhanced drug efficacy.

作者信息

Yang Su, Xu Dawei, Dong He

机构信息

Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.

出版信息

J Mater Chem B. 2018 Nov 28;6(44):7179-7184. doi: 10.1039/c8tb00728d. Epub 2018 May 2.

DOI:10.1039/c8tb00728d
PMID:32254632
Abstract

This work demonstrates a modular design strategy based on the supramolecular assembly of multidomain peptides to fabricate reduction-responsive cell penetrating nanofibers (CPNs), which hold great promise for selective targeting of cancer therapeutics to tumor cells.

摘要

这项工作展示了一种基于多结构域肽超分子组装的模块化设计策略,用于制造还原响应性细胞穿透纳米纤维(CPN),这对于将癌症治疗剂选择性靶向肿瘤细胞具有巨大潜力。

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Modular design and self-assembly of multidomain peptides towards cytocompatible supramolecular cell penetrating nanofibers.用于细胞相容性超分子细胞穿透纳米纤维的多结构域肽的模块化设计与自组装
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Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity.
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Combined Tumor Environment Triggered Self-Assembling Peptide Nanofibers and Inducible Multivalent Ligand Display for Cancer Cell Targeting with Enhanced Sensitivity and Specificity.联合肿瘤环境触发的自组装肽纳米纤维及用于癌细胞靶向的可诱导多价配体展示,具有增强的敏感性和特异性
Small. 2020 Sep;16(38):e2002780. doi: 10.1002/smll.202002780. Epub 2020 Aug 18.