Zhang Mingzhu, Du Wei, Tian Xiaohe, Zhang Ruilong, Zhao Meng, Zhou Hongping, Ding Yaqi, Li Lin, Wu Jieying, Tian Yupeng
Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, China.
J Mater Chem B. 2018 Jul 21;6(27):4417-4421. doi: 10.1039/c8tb00976g. Epub 2018 Jun 27.
We report that a dicyanyl derivative QN2 containing quaternary ammonium was capable of identifying apoptotic cells by targeting nucleic acid (DNA and RNA) and we were able to observe nuclear ultra-details using a stimulated emission depletion (STED) nanoscopy technique. QN2 could evaluate the anti-cancer drug pesticide effect by monitoring in real-time without interfering with normal cell proliferation. These results suggest the high potential for using QN2 in practice for monitoring apoptosis to evaluate tumor therapy effectiveness or for drug development.
我们报告称，一种含季铵盐的二氰基衍生物QN2能够通过靶向核酸（DNA和RNA）来识别凋亡细胞，并且我们能够使用受激发射损耗（STED）纳米显微镜技术观察到细胞核的超微细节。QN2可以通过实时监测来评估抗癌药物的农药效果，而不会干扰正常细胞的增殖。这些结果表明，QN2在实际应用中具有很高的潜力，可用于监测细胞凋亡以评估肿瘤治疗效果或用于药物开发。
