Department of Chemistry, Petit Science Center, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA, 30303, USA.
Center for Diagnostics and Therapeutics. Petit Science Center, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA, 30303, USA.
Chemistry. 2021 Mar 1;27(13):4230-4248. doi: 10.1002/chem.202003697. Epub 2020 Dec 29.
Cyanine dyes carrying quinoline moieties are an important class of organic molecules that are of great interest for applications in many fields like medicine, pharmacology, and engineering. Despite their exceptional properties, such as stability, high molar extinction coefficients, and high pH-sensitivity, this class of dyes has been less analyzed and reviewed in the last few decades. Therefore, this review article focuses on discussing the history of quinoline compounds, various synthetic routes to prepare quinolinium salts and symmetrical and asymmetrical mono-, di-, tri-, penta- and heptamethine cyanine dyes, containing quinoline moieties, together with their optical properties and applications as photosensitizers in photodynamic therapy, probes in biomolecules for labeling of nucleic acids, as well as imaging agents.
带有喹啉部分的菁染料是一类重要的有机分子，它们在医学、药理学和工程学等许多领域的应用中具有重要的意义。尽管它们具有稳定性、高摩尔消光系数和高 pH 灵敏度等优异的性质，但在过去几十年中，对这类染料的分析和综述较少。因此，本文重点讨论了喹啉化合物的历史，以及各种合成途径来制备喹啉鎓盐以及含有喹啉部分的对称和不对称单、二、三、五和七甲川菁染料，以及它们作为光动力治疗中的光敏剂、生物分子中核酸标记的探针以及成像剂的光学性质和应用。
