Santha Moorthy Madhappan, Hoang Giang, Subramanian Bharathiraja, Bui Nhat Quang, Panchanathan Manivasagan, Mondal Sudip, Thi Tuong Vy Phan, Kim Hyehyun, Oh Junghwan
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea.
J Mater Chem B. 2018 Aug 28;6(32):5220-5233. doi: 10.1039/c8tb01214h. Epub 2018 Jul 26.
The fabrication of nanotherapeutic systems capable of stimuli-responsive drug delivery and photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is considered significant for chemo-photothermal therapy applications in cancer therapy. In the present study, the Prussian blue nanoflake (PBNF) decorated mesoporous silica hybrid nanoparticle (PB@MSH-EDA NPs) is reported for PAI-guided chemo-photothermal therapy applications. The amine group enriched mesoporous silica channels can be used to encapsulate an anticancer drug for chemotherapy, and the surface decorated PBNFs can convert a near-infrared (NIR) laser (808 nm) into heat for photothermal therapy and can also be used for PAI applications. The PB@MSH-EDA NPs show pH-responsive drug release efficiency under acidic pH (pH 5.0 and 4.0) conditions. Furthermore, the PB@MSH-EDA NPs system shows strong NIR laser absorption and photothermal conversion efficiency under 808 nm laser irradiation. The in vitro experimental result shows that the PB@MSH-EDA NPs are biocompatible and could be efficiently taken up by MDA-MB-231 cells. In addition, the in vivo results demonstrate that the tumor-bearing mice fully recovered after injecting the drug (Dox)-loaded PB@MSH-EDA/Dox NPs and being further irradiated with the 808 nm laser. We believe that the PB@MSH-EDA NPs system could be utilized as an efficient PAI-guided chemo-photothermal therapy agent for the detection and treatment of tumors in an emerging cancer therapy application.
能够进行刺激响应性药物递送和光声成像（PAI）引导的光热疗法（PTT）的纳米治疗系统的制备被认为对癌症治疗中的化学光热疗法应用具有重要意义。在本研究中，报道了普鲁士蓝纳米片（PBNF）修饰的介孔二氧化硅杂化纳米颗粒（PB@MSH-EDA NPs）用于PAI引导的化学光热疗法应用。富含胺基的介孔二氧化硅通道可用于封装抗癌药物以进行化疗，表面修饰的PBNF可将近红外（NIR）激光（808 nm）转化为热量用于光热疗法，还可用于PAI应用。PB@MSH-EDA NPs在酸性pH（pH 5.0和4.0）条件下表现出pH响应性药物释放效率。此外，PB@MSH-EDA NPs系统在808 nm激光照射下表现出强烈的NIR激光吸收和光热转换效率。体外实验结果表明，PB@MSH-EDA NPs具有生物相容性，可被MDA-MB-231细胞有效摄取。此外，体内结果表明，注射载药（阿霉素）的PB@MSH-EDA/Dox NPs并进一步用808 nm激光照射后，荷瘤小鼠完全康复。我们相信，PB@MSH-EDA NPs系统可作为一种高效的PAI引导的化学光热疗法药物，用于新兴癌症治疗应用中的肿瘤检测和治疗。
