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普鲁士蓝基双荧光和磁共振对比剂（CA）的合成及初步临床应用。

Synthesis and preclinical application of a Prussian blue-based dual fluorescent and magnetic contrast agent (CA).

机构信息

Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.

Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary.

出版信息

PLoS One. 2022 Jul 20;17(7):e0264554. doi: 10.1371/journal.pone.0264554. eCollection 2022.

DOI:10.1371/journal.pone.0264554
PMID:35857783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9299340/
Abstract

The aim of this study was to develop and characterize a Prussian Blue based biocompatible and chemically stable T1 magnetic resonance imaging (MRI) contrast agent with near infrared (NIR) optical contrast for preclinical application. The physical properties of the Prussian blue nanoparticles (PBNPs) (iron (II); iron (III);octadecacyanide) were characterized with dynamic light scattering (DLS), zeta potential measurement, atomic force microscopy (AFM), and transmission electron microscopy (TEM). In vitro contrast enhancement properties of PBNPs were determined by MRI. In vivo T1-weighted contrast of the prepared PBNPs was investigated by MRI and optical imaging modality after intravenous administration into NMRI-Foxn1 nu/nu mice. The biodistribution studies showed the presence of PBNPs predominantly in the cardiovascular system. Briefly, in this paper we show a novel approach for the synthesis of PBNPs with enhanced iron content for T1 MRI contrast. This newly synthetized PBNP platform could lead to a new diagnostic agent, replacing the currently used Gadolinium based substances.

摘要

本研究旨在开发和表征一种普鲁士蓝基生物相容性和化学稳定性 T1 磁共振成像（MRI）造影剂，具有近红外（NIR）光学对比度，用于临床前应用。普鲁士蓝纳米粒子（PBNPs）（铁（II）；铁（III）；十八氰化物）的物理性质用动态光散射（DLS）、zeta 电位测量、原子力显微镜（AFM）和透射电子显微镜（TEM）进行了表征。通过 MRI 测定了 PBNPs 的体外对比增强特性。通过静脉注射到 NMRI-Foxn1 nu/nu 小鼠后，通过 MRI 和光学成像方式研究了制备的 PBNPs 的体内 T1 加权对比。生物分布研究表明，PBNPs 主要存在于心血管系统中。简而言之，本文展示了一种新的方法，用于合成具有增强的 T1 MRI 对比度的铁含量的 PBNPs。这个新合成的 PBNP 平台可以开发出一种新的诊断试剂，替代目前使用的钆基物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/efe8559eaaae/pone.0264554.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/d729b31387fe/pone.0264554.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/4921d7986019/pone.0264554.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/fc5fa227766c/pone.0264554.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/cde02f1b093a/pone.0264554.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/efe8559eaaae/pone.0264554.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/d729b31387fe/pone.0264554.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/4921d7986019/pone.0264554.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/fc5fa227766c/pone.0264554.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/cde02f1b093a/pone.0264554.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510c/9299340/efe8559eaaae/pone.0264554.g005.jpg

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Correction: Synthesis and preclinical application of a Prussian blue-based dual fluorescent and magnetic contrast agent (CA).更正：基于普鲁士蓝的双荧光和磁性造影剂（CA）的合成及临床前应用
PLoS One. 2023 Nov 30;18(11):e0295460. doi: 10.1371/journal.pone.0295460. eCollection 2023.

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