Unversidad CEU San Pablo, Spain.
J Mater Chem B. 2019 Mar 28;7(12):1974-1985. doi: 10.1039/c8tb02738b. Epub 2019 Feb 27.
Musculoskeletal disorders such as osteoporosis and rheumatoid arthritis are responsible for more than 25k deaths every year in the European Union and constitute a chronic burden on the individuals who suffer from this condition. There is no medical cure for these diseases and there are many therapies applied which have limited effectiveness and severe side effects over time. Regenerative therapies are being studied as a potential treatment for musculoskeletal diseases and are known for their upgrading effects of the natural healing processes carried out in the human body. It is believed that both strontium and zinc play an essential role in bone and cartilage tissue formation, which has led many scientists to study the effect of including these elements to promote tissue formation and inhibit its resorption. In this review, a deep analysis is undertaken of the most relevant developments in strontium and zinc based regenerative therapies that have occurred in the last five years, taking into consideration only those studies reporting significant progress towards real clinical applications. This review brings up to date the state of the art of strontium and zinc based regenerative therapies as it is believed that both have a promoting effect on tissue formation and have an essential role inhibiting resorption in musculoskeletal disorders.
肌肉骨骼疾病，如骨质疏松症和类风湿性关节炎，每年在欧盟导致超过 2.5 万人死亡，对患有这种疾病的人来说是一种慢性负担。目前这些疾病还没有治愈方法，有许多应用的疗法，随着时间的推移，其有效性有限且副作用严重。再生疗法正被研究作为治疗肌肉骨骼疾病的一种潜在方法，并且因其对人体自然愈合过程的升级作用而闻名。人们认为锶和锌在骨和软骨组织形成中起着至关重要的作用，这促使许多科学家研究包括这些元素以促进组织形成和抑制其吸收的效果。在这篇综述中，仅考虑那些报告在真正的临床应用方面取得重大进展的研究，对过去五年中发生的基于锶和锌的再生疗法的最相关进展进行了深入分析。这篇综述更新了基于锶和锌的再生疗法的最新进展，因为人们认为它们都对组织形成有促进作用，并且在肌肉骨骼疾病中对抑制吸收有重要作用。
