Li Ping, Dai Jingtao, Li Yageng, Alexander Dorothea, Čapek Jaroslav, Geis-Gerstorfer Jürgen, Wan Guojiang, Han Jianmin, Yu Zhentao, Li An
Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, South Jiangnan Road No. 366, Guangzhou 510280, China.
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Mater Today Bio. 2023 Dec 28;25:100932. doi: 10.1016/j.mtbio.2023.100932. eCollection 2024 Apr.
Bone fractures and critical-size bone defects are significant public health issues, and clinical treatment outcomes are closely related to the intrinsic properties of the utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because of their exceptional biocompatibility, appropriate mechanical properties, and controllable biodegradation. This review summarizes the state of the art in terms of Zn-based metals for bone repair and regeneration, focusing on bridging the gap between biological mechanism and required bioactivity. The molecular mechanism underlying the release of Zn ions from Zn-based BMs in the improvement of bone repair and regeneration is elucidated. By integrating clinical considerations and the specific bioactivity required for implant materials, this review summarizes the current research status of Zn-based internal fixation materials for promoting fracture healing, Zn-based scaffolds for regenerating critical-size bone defects, and Zn-based barrier membranes for reconstituting alveolar bone defects. Considering the significant progress made in the research on Zn-based BMs for potential clinical applications, the challenges and promising research directions are proposed and discussed.
骨折和临界尺寸骨缺损是重大的公共卫生问题，临床治疗结果与所用植入材料的固有特性密切相关。锌（Zn）基可生物降解金属由于其优异的生物相容性、适当的机械性能和可控的生物降解性，已成为有前途的生物活性材料。本文综述了锌基金属在骨修复和再生方面的研究现状，重点是弥合生物学机制与所需生物活性之间的差距。阐明了锌基可生物降解金属释放锌离子促进骨修复和再生的分子机制。通过结合临床考虑因素和植入材料所需的特定生物活性，本文总结了锌基内固定材料促进骨折愈合、锌基支架修复临界尺寸骨缺损以及锌基屏障膜修复牙槽骨缺损的当前研究现状。考虑到锌基可生物降解金属在潜在临床应用研究中取得的重大进展，提出并讨论了面临的挑战和有前景的研究方向。
