Zheng Youkun, Liu Weiwei, Chen Yun, Jiang Hui, Wang Xuemei
State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
J Mater Chem B. 2018 Jun 14;6(22):3650-3654. doi: 10.1039/c8tb00791h. Epub 2018 May 24.
Herein, we demonstrate a novel, facile, and suitable strategy for imaging GSH based on mercaptopyrimidine-directed gold nanoclusters (Au NCs). GSH can specifically induce the fluorescence enhancement of Au NCs by attacking the surface of the NCs to form dual ligand stabilized Au NCs at the millimolar level. Very importantly, the Au NCs can selectively image cancer cells.
在此，我们展示了一种基于巯基嘧啶导向的金纳米簇（Au NCs）对谷胱甘肽（GSH）进行成像的新颖、简便且适用的策略。GSH可通过攻击纳米簇表面以毫摩尔水平形成双配体稳定的Au NCs，从而特异性地诱导Au NCs的荧光增强。非常重要的是，Au NCs能够选择性地对癌细胞进行成像。
