Tang Mingxiu, Zhang Jian, Yang Chunyan, Zheng Youkun, Jiang Hui
The Second Affiliated Hospital, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Key Laboratory of Medical Electrophysiology of Ministry of Education, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.
Front Chem. 2020 Mar 24;8:181. doi: 10.3389/fchem.2020.00181. eCollection 2020.
Infections caused by antibiotic-resistant bacteria have become one of the most serious global public health crises. Early detection and effective treatment can effectively prevent deterioration and further spreading of the bacterial infections. Therefore, there is an urgent need for time-saving diagnosis as well as therapeutically potent therapy approaches. Development of nanomedicine has provided more choices for detection and therapy of bacterial infections. Ultrasmall gold nanoclusters (Au NCs) are emerging as potential antibacterial agents and have drawn intense attention in the biomedical fields owing to their excellent biocompatibility and unusual physicochemical properties. Recent significant efforts have shown that these versatile Au NCs also have great application potential in the selective detection of bacteria and infection treatment. In this review, we will provide an overview of research progress on the development of versatile Au NCs for bacterial detection and infection treatment, and the mechanisms of action of designed diagnostic and therapeutic agents will be highlighted. Based on these cases, we have briefly discussed the current issues and perspective of Au NCs for bacterial detection and infection treatment applications.
由抗生素耐药细菌引起的感染已成为最严重的全球公共卫生危机之一。早期检测和有效治疗可有效预防细菌感染的恶化和进一步传播。因此，迫切需要节省时间的诊断方法以及具有强大治疗效果的治疗方法。纳米医学的发展为细菌感染的检测和治疗提供了更多选择。超小金纳米团簇（Au NCs）作为潜在的抗菌剂正在兴起，由于其优异的生物相容性和独特的物理化学性质，在生物医学领域引起了广泛关注。最近的大量研究表明，这些多功能的Au NCs在细菌的选择性检测和感染治疗方面也具有巨大的应用潜力。在这篇综述中，我们将概述多功能Au NCs用于细菌检测和感染治疗的研究进展，并重点介绍所设计的诊断和治疗剂的作用机制。基于这些案例，我们简要讨论了Au NCs在细菌检测和感染治疗应用中的当前问题和前景。
