Kanaya F
Department of Orthopaedic Surgery, Niigata University School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1988 Jun;62(6):635-51.
The efficacy of causing muscle atrophy was compared among denervation, arthrodesis and tenotomy in rat anterior tibial muscle. Reduction of wet weight was most pronounced in denervated muscle and least in arthrodesed muscle. Histochemical investigation by ATPase stain revealed that atrophy of Type 1 and Type 2 fiber was more severe in denervated muscle group than in the other two groups. Type 2 fiber atrophy was dominant in denervated muscle and in arthrodesed muscle. Type 1 fiber atrophy was dominant in tenotomized muscle. The effect of electrostimulation on denervated muscle was investigated. Electrostimulation significantly reduced the degree of denervation atrophy. Four weeks after severance of peroneal nerve, tibial nerve-crossing was done and electrostimulation was continued for eight weeks. Recovery of wet weight of re-innervated muscle with electrostimulation was significantly better than that without electrostimulation. Electrostimulation applied to denervated muscle reduced the progress of atrophy and improved the recovery after nerve repair.
在大鼠胫前肌中，比较了去神经支配、关节固定和肌腱切断术导致肌肉萎缩的效果。去神经支配的肌肉湿重减少最为明显，关节固定的肌肉湿重减少最少。通过ATP酶染色进行的组织化学研究表明，去神经支配肌肉组中1型和2型纤维的萎缩比其他两组更严重。2型纤维萎缩在去神经支配的肌肉和关节固定的肌肉中占主导地位。1型纤维萎缩在肌腱切断的肌肉中占主导地位。研究了电刺激对去神经支配肌肉的影响。电刺激显著降低了去神经支配萎缩的程度。在腓总神经切断4周后，进行胫神经交叉，并继续电刺激8周。电刺激下重新获得神经支配的肌肉的湿重恢复明显优于无电刺激的情况。对去神经支配的肌肉施加电刺激可减少萎缩进程，并改善神经修复后的恢复情况。
