Cai Qi, Xu Jiating, Yang Dan, Dai Yunlu, Yang Guixin, Zhong Chongna, Gai Shili, He Fei, Yang Piaoping
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
J Mater Chem B. 2018 Dec 28;6(48):8148-8162. doi: 10.1039/c8tb02407c. Epub 2018 Nov 23.
Designing multifunctional nanoplatforms for the purpose of simultaneous theranostic modalities is critical to address the challenges of cancer therapy. Also, single modalities of phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), cannot meet the requirements of highly efficient treatment. Here, a core-shell-shell nanostructure consisting of a core of upconversion nanoparticles (UCNPs), a layer of mesoporous silica with anchored ZnO nanodots, and an outer layer of polypyrrole (PPy) was developed. In the proposed construct, the emitted ultraviolet (UV) light from the UCNPs core upon 980 nm near-infrared light irradiation can trigger the ZnO nanodots to activate ambient O molecules around cancerous tissues to produce toxic reactive oxygen species (ROS), realizing the PDT function. On the other hand, the coated PPy layer can concurrently give rise to an obvious heat effect upon NIR light illumination, thus achieving synergistic PDT and PTT effects; this results in excellent anti-tumor efficiency in vitro and in vivo. Furthermore, in hand with the upconversion luminescence (UCL) and computed tomography (CT) imaging derived from the UCNPs core, dual-mode imaging directed cancer therapy has been realized.
设计用于同时进行治疗诊断的多功能纳米平台对于应对癌症治疗挑战至关重要。此外，光疗的单一模式，包括光热疗法（PTT）和光动力疗法（PDT），无法满足高效治疗的要求。在此，开发了一种核壳壳纳米结构，其核心为上转换纳米颗粒（UCNP），中间层为锚定有ZnO纳米点的介孔二氧化硅，外层为聚吡咯（PPy）。在所提出的结构中，980nm近红外光照射下，UCNP核心发射的紫外（UV）光可触发ZnO纳米点，激活癌组织周围的环境O分子以产生活性氧（ROS），实现PDT功能。另一方面，包覆的PPy层在近红外光照射下可同时产生明显的热效应，从而实现PDT和PTT的协同效应；这在体外和体内均产生了优异的抗肿瘤效率。此外，结合UCNP核心产生的上转换发光（UCL）和计算机断层扫描（CT）成像，实现了双模式成像引导的癌症治疗。
