Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
J Mater Chem B. 2019 Mar 7;7(9):1435-1441. doi: 10.1039/c8tb03206h. Epub 2019 Feb 5.
A water-soluble two-dimensional supramolecular organic framework (2D SOF) was prepared via self-assembly of cucurbit[8]uril (CB[8]) and a three-arm flat linker molecule, which contains a benzene ring as the core and three Brooker's merocyanine (BM) analogs as arms. The strong host-guest interactions between BM and CB[8] and the directional head-to-tail stacking modes between the BM arms synergistically led to the formation of a 2D SOF. The structure of the 2D SOF was verified by H NMR, 2D H NMR NOESY, and DLS characterizations, while the monolayer structure was characterized by Cryo-TEM and AFM measurements. The 2D SOF exhibited an obvious AIE enhancement effect in HO. In addition, DNA induced photoluminescence enhancement was observed for the monomer. As a result, this AIEgen-based 2D SOF could feature not only as a cell visualizer but also as a tracker for the nucleus in biological imaging due to the dynamic assembly process.
一种水溶性二维超分子有机框架（2D SOF）通过葫芦[8]脲（CB[8]）和三臂扁平连接分子的自组装制备而成，该连接分子包含苯环作为核心和三个 Brooker 的变色氰（BM）类似物作为臂。BM 与 CB[8]之间的强主客体相互作用和 BM 臂之间的定向头尾堆积模式协同导致了 2D SOF 的形成。2D SOF 的结构通过 1H NMR、2D 1H NMR NOESY 和 DLS 表征得到验证，而单层结构则通过 Cryo-TEM 和 AFM 测量得到表征。2D SOF 在 HO 中表现出明显的聚集诱导发光增强效应。此外，单体还观察到 DNA 诱导的荧光增强。因此，由于动态组装过程，基于这种 AIEgen 的 2D SOF 不仅可以用作细胞可视化剂，还可以用作生物成像中的核追踪剂。
