State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
J Mater Chem B. 2019 Mar 21;7(11):1824-1841. doi: 10.1039/c8tb03124j. Epub 2019 Feb 15.
Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery systems that encapsulate nucleic acids and deliver them to effective sites in the cell. Due to the insecurity of viral vectors, non-viral vectors have gained great attention recently. Additional advantages of non-viral vectors include their safety, flexibility in packaging nucleic acids, and ease of production. To construct an ideal gene carrier, peptides can be incorporated into non-viral gene delivery systems as functional motifs to overcome the current barriers in gene delivery. In this review, we summarize recent developments in peptide-based gene delivery vector research.
基因治疗作为一种疾病治疗策略，需要安全有效的基因传递系统，该系统能够包裹核酸并将其递送至细胞中的有效部位。由于病毒载体的不安全性，最近非病毒载体引起了广泛关注。非病毒载体的额外优点包括其安全性、包装核酸的灵活性以及易于生产。为了构建理想的基因载体，可以将肽整合到非病毒基因传递系统中作为功能基元，以克服基因传递中的当前障碍。在这篇综述中，我们总结了基于肽的基因传递载体研究的最新进展。
