The Biotechnology & Drug Development Research Laboratory, Curtin Medical School & Curtin Health Innovation Research Institute, Curtin University, Bentley, 6102, Western Australia, Australia.
Department of Clinical Biochemistry, Pathwest Laboratory Medicine, Royal Perth Hospital, Perth, 6000, Western Australia, Australia.
Ther Deliv. 2024;15(10):801-818. doi: 10.1080/20415990.2024.2389032. Epub 2024 Sep 26.
Hearing loss places a significant burden on our aging population. However, there has only been limited progress in developing therapeutic techniques to effectively mediate this condition. This review will outline several of the most commonly utilized practices for the treatment of sensorineural hearing loss before exploring more novel techniques currently being investigated via both and research. This review will place particular emphasis on novel gene-delivery technologies. Primarily, it will focus on techniques used to deliver genes that have been shown to encourage the proliferation and differentiation of sensory cells within the inner ear and how these technologies may be translated into providing clinically useful results for patients.
听力损失给我们的老年人口带来了巨大的负担。然而，在开发治疗技术以有效缓解这种情况方面，进展非常有限。本综述将概述几种治疗感音神经性听力损失最常用的方法，然后探讨目前通过基础研究和临床前研究正在研究的更新型技术。本综述将特别强调新型基因传递技术。主要集中在用于传递基因的技术上，这些技术已被证明可以促进内耳中感觉细胞的增殖和分化，以及这些技术如何转化为为患者提供临床有用的结果。
