Chou Ying-Nien, Venault Antoine, Wang Yu-Hsiang, Chinnathambi Arunachalam, Higuchi Akon, Chang Yung
R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan 320, Taiwan.
J Mater Chem B. 2018 Aug 14;6(30):4909-4919. doi: 10.1039/c8tb01054d. Epub 2018 Jun 11.
Amphiphilic zwitterionic copolymers have a severe problem of solubility, which restricts the feasibility and development of antifouling coatings. In this work, zwitterionic polymers were grafted via a novel modification method, namely, in situ self-assembling coating (ISC), which consists of synthesizing and simultaneously coating a copolymer onto a surface. This resolves the dissolution problem of amphiphilic zwitterionic copolymers. Here, the ISC method was applied to a copolymer composed of hydrophobic styrene (ST) and hydrophilic sulfobetaine methacrylate (SBMA). Under optimized conditions of concentration, molar ratio, and reaction time, the amphiphilic copolymer, poly(styrene-co-sulfobetaine methacrylate) (PS-PSBMA), can be coated onto the substrate surface. Ultralow protein adsorption from single-protein solutions and reduction of attachments from human blood platelets, erythrocytes, leukocytes, tissue cells, and bacteria were achieved. The mechanism of ISC was explained by carrying out time-dependent fibrinogen adsorption tests, along with particle size measurements in the polymerization bath. Furthermore, the ISC method was applied to versatile hydrophobic materials including polypropylene (PP), poly(dimethylsiloxane) (PDMS), and poly(tetrafluoroethylene) (PTFE). This work introduces a unique, convenient, and efficient method for synthesizing and coating amphiphilic zwitterionic polymers in a single step for antifouling applications in complex media.
两亲性两性离子共聚物存在严重的溶解性问题，这限制了防污涂层的可行性和发展。在这项工作中，通过一种新颖的改性方法，即原位自组装涂层（ISC）来接枝两性离子聚合物，该方法包括在表面上合成并同时涂覆共聚物。这解决了两亲性两性离子共聚物的溶解问题。在此，ISC方法应用于由疏水性苯乙烯（ST）和亲水性甲基丙烯酸磺基甜菜碱（SBMA）组成的共聚物。在浓度、摩尔比和反应时间的优化条件下，两亲性共聚物聚（苯乙烯 - 甲基丙烯酸磺基甜菜碱）（PS - PSBMA）可以涂覆在基材表面。实现了从单蛋白溶液中的超低蛋白吸附以及人血小板、红细胞、白细胞、组织细胞和细菌附着的减少。通过进行随时间变化的纤维蛋白原吸附测试以及在聚合浴中测量粒径来解释ISC的机理。此外，ISC方法应用于包括聚丙烯（PP）、聚二甲基硅氧烷（PDMS）和聚四氟乙烯（PTFE）在内的多种疏水性材料。这项工作引入了一种独特、方便且高效的方法，可在一步中合成并涂覆两亲性两性离子聚合物，用于复杂介质中的防污应用。
