Shen Yue-Qin, Zhu Ying-Jie, Chen Fei-Fei, Jiang Ying-Ying, Xiong Zhi-Chao, Chen Feng
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.
J Mater Chem B. 2018 Aug 14;6(30):4985-4994. doi: 10.1039/c8tb00881g. Epub 2018 Jul 19.
The development of multifunctional dental-restorative biomaterials with antibacterial activity and remineralization effect for damaged tooth repair is urgent since dental caries is still one of the most common tooth diseases in human beings. Herein, we report a facile strategy for the synthesis of gluey silver-calcium phosphate (GSCP) composites using the rapid microwave-assisted solvothermal method. The as-prepared GSCP composite is an organic-inorganic hybrid, and Ag ions display a significant influence on the formation of GSCP by interacting with adenosine triphosphate biomolecules. The as-prepared GSCP composite shows good antibacterial properties, in addition, it exhibits a great effect on sheltering dentinal canaliculi and improving the remineralization of dentine in the simulated saliva. The as-prepared GSCP composite is promising for various applications such as oral healthcare, especially, remineralization of dentine, and antibacterial applications.
由于龋齿仍是人类最常见的牙齿疾病之一，因此开发具有抗菌活性和再矿化作用的多功能牙齿修复生物材料以修复受损牙齿迫在眉睫。在此，我们报道了一种使用快速微波辅助溶剂热法合成粘性磷酸银钙（GSCP）复合材料的简便策略。所制备的GSCP复合材料是一种有机-无机杂化材料，银离子通过与三磷酸腺苷生物分子相互作用，对GSCP的形成有显著影响。所制备的GSCP复合材料具有良好的抗菌性能，此外，它在模拟唾液中对保护牙本质小管和改善牙本质再矿化方面表现出很大的效果。所制备的GSCP复合材料在口腔保健等各种应用中具有广阔前景，特别是牙本质再矿化和抗菌应用。
