尿酸基因多态性与非洲裔南非人先兆子痫有关。
Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry.
机构信息
Optics and Imaging Centre, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Third Department of Internal Medicine, University of Fukui Faculty of Medicine Sciences, Fukui, Japan.
出版信息
Hypertens Pregnancy. 2020 May;39(2):103-116. doi: 10.1080/10641955.2020.1741608. Epub 2020 Apr 7.
: To investigate the association of uric acid gene polymorphisms and Pre-eclampsia.: 637 women of African ancestry [280 controls, 357 pre-eclampsia (early-onset = 187, late-onset = 170]) retrospectively. The rs505802, rs1212986, and rs1014290 SNPs were genotyped from purified DNA using real-time PCR.: CT genotype (rs505802) was higher in pre-eclampsia [Adjusted : OR (95% CI) = 1.73 (1.258-2.442)] and late-onset pre-eclampsia [Adjusted : OR (95% CI) = 1.75 (1.165-2.2628)] than controls. CT genotype (rs1014290) was higher in early-onset pre-eclampsia [Adjusted p-value : OR (95% CI) = 1.60 (1.102-2.325)] than controls.: The genotyped rs505802 and rs1014290 are significantly associated with pre-eclampsia.
目的
探讨尿酸基因多态性与子痫前期的相关性。
方法
回顾性分析 637 例非裔美国女性（280 例对照，357 例子痫前期[早发型=187 例，晚发型=170 例]）。采用实时 PCR 从纯化 DNA 中对 rs505802、rs1212986 和 rs1014290 SNP 进行基因分型。
结果
子痫前期患者 CT 基因型（rs505802）高于对照组[校正：比值比（95%可信区间）=1.73（1.258-2.442）]和晚发型子痫前期[校正：比值比（95%可信区间）=1.75（1.165-2.2628）]。早发型子痫前期患者 CT 基因型（rs1014290）高于对照组[校正 p 值：比值比（95%可信区间）=1.60（1.102-2.325）]。
结论
rs505802 和 rs1014290 基因型与子痫前期显著相关。
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