南非黑人女性肾素-血管紧张素-醛固酮系统四个组分的基因多态性与子痫前期的关联
Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women.
作者信息
Aung M, Konoshita T, Moodley J, Gathiram P
机构信息
Department of Family Medicine, University of KwaZulu-Natal, Durban, South Africa.
Third Department of Internal Medicine, University of Fukui Faculty of Medicine Sciences, Fukui, Japan.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2017 Aug;215:180-187. doi: 10.1016/j.ejogrb.2017.05.011. Epub 2017 May 18.
OBJECTIVE
To investigate the association of the gene polymorphisms of: angiotensinogen (AGT), renin (REN), angiotensin II receptor 1 (AT1R) and angiotensin II receptor 2 (AT2R), in the pathogenesis of PE in South African Black women.
METHODOLOGY (STUDY DESIGN): 603 pregnant women; 246 normotensive and 357 with PE (early-onset=187, late-onset=170), were recruited. Each study group was subdivided into HIV infected and uninfected groups. The distribution and frequencies of gene polymorphisms of AGT (M235T), REN (C-5312T), AT1R (A1166C) and AT2R (C3123A) were determined in purified DNA by Real Time Polymerase Chain Reaction.
RESULTS
The distribution of T allele and TT genotype of AGT in PE were significantly higher than the normotensive group (95% vs 91%, OR 1.9, 95%CI 1.2-3.1, p=0.0051; 90% vs 83%, OR 1.84, 95%CI 1.11-3.05, p=0.01) respectively. The distributions of genotypes of REN, AT1R and AT2R were similar in PE and normotensive groups.
CONCLUSION
The T allele of AGT may play a role in the pathogenesis of PE. The genotypes of REN, AT1R and AT2R were not associated with the development of PE.
目的
研究血管紧张素原（AGT）、肾素（REN）、血管紧张素II受体1（AT1R）和血管紧张素II受体2（AT2R）的基因多态性与南非黑人女性先兆子痫发病机制之间的关联。
方法（研究设计）：招募了603名孕妇，其中246名血压正常，357名患有先兆子痫（早发型=187例，晚发型=170例）。每个研究组又分为感染HIV和未感染HIV的组。通过实时聚合酶链反应在纯化的DNA中测定AGT（M235T）、REN（C-5312T）、AT1R（A1166C）和AT2R（C3123A）基因多态性的分布和频率。
结果
先兆子痫组中AGT的T等位基因和TT基因型的分布显著高于血压正常组（分别为95%对91%，比值比1.9，95%置信区间1.2 - 3.1，p = 0.0051；90%对83%，比值比1.84，95%置信区间1.11 - 3.05，p = 0.01）。先兆子痫组和血压正常组中REN、AT1R和AT2R的基因型分布相似。
结论
AGT的T等位基因可能在先兆子痫的发病机制中起作用。REN、AT1R和AT2R的基因型与先兆子痫的发生无关。
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