Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Academic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ocul Immunol Inflamm. 2021 Jul 4;29(5):982-990. doi: 10.1080/09273948.2019.1709650. Epub 2020 Apr 7.
: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures for AC flare.: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability.: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading was 0.40-0.93 and 0.87-0.94 for LFP and protein concentration. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM.: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.
前房（AC）闪光是前葡萄膜炎的一个关键征象。用于测量 AC 闪光的新型基于仪器的技术可以提供自动化和客观性。本综述旨在确定用于 AC 闪光的客观基于仪器的测量方法。
在这项系统评价中，我们确定了报道仪器检测与临床医生 AC 闪光分级之间相关性的研究，以及/或与房水蛋白浓度的相关性，以及检测的可靠性。
在 11 项研究中确定了 4 项指标检测：激光闪光光度计（LFP）、光学相干断层扫描、眼内闪光分析仪（OFAM）和双通技术。LFP 与临床医生分级的相关性为 0.40-0.93，与 LFP 和蛋白质浓度的相关性为 0.87-0.94。双通技术与临床医生分级无相关性，而 OFAM 的信息不足。
LFP 与临床医生分级和房水蛋白浓度具有中等至强相关性。LFP 可能是一种优于临床医生 AC 闪光分级的参考测试，可用于验证新的指标检测。
