Bilici Serdar, Gültekin Erol Tuba, Küçük Numan, Uğurbaş Suat Hayri
Department of Ophthalmology, Faculty of Medicine, School of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Int Ophthalmol. 2025 Jul 24;45(1):315. doi: 10.1007/s10792-025-03680-6.
To evaluate systemic inflammatory marker levels in Irvine-Gass Syndrome (IGS) cases and to compare with uncomplicated cataract (control) cases.
Medical records of 25 IGS cases and 30 control cases were retrospectively analyzed. Levels of neutrophils, monocytes, lymphocytes, and thrombocytes were obtained from blood samples. Systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated and compared between the two groups. In case of significant difference presence, the receiver operating characteristic curve (ROC) analysis was performed to determine the best cutoff value of systemic inflammatory markers in IGS.
The medians (min-max) of NLR, PLR, SII, and SIRI were 2.59 (0.13-16.50), 118.42 (5.49-297.69), 525.18 (22.5-3217.5), and 1.44 (0.06-10.11) in IGS group; 1.62 (0.93-8.50), 98.69 (70.0-400.0), 380.60 (161.0-2040.0), and 0.79 (0.37-5.10) in control group, respectively. SIRI was significantly higher in the IGS group (p = 0.036) in comparison to the control group. NLR, PLR, and SII were also found higher in the IGS group, but this difference couldn't reach statistical significance level (p = 0.101, p = 0.600, and p = 0.176, respectively). The ROC analysis revealed that the area under the curve for SIRI to distinguish IGS found to be 0.665. The best cutoff value of SIRI was 0.95, with a sensitivity of 64% and specificity 73%.
Higher levels of SIRI in IGS cases may indicate the potential association between subclinical systemic inflammation and pseudophakic cystoid edema formation. The current results highlight the potential utility of SIRI as a predictive factor for IGS following cataract surgery.
评估Irvine-Gass综合征（IGS）患者的全身炎症标志物水平，并与单纯性白内障（对照组）患者进行比较。
回顾性分析25例IGS患者和30例对照患者的病历。从血样中获取中性粒细胞、单核细胞、淋巴细胞和血小板的水平。计算并比较两组患者的全身炎症标志物，包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）。若存在显著差异，则进行受试者工作特征曲线（ROC）分析，以确定IGS中全身炎症标志物的最佳截断值。
IGS组中NLR、PLR、SII和SIRI的中位数（最小值-最大值）分别为2.59（0.13-16.50）、118.42（5.49-297.69）、525.18（22.5-3217.5）和1.44（0.06-10.11）；对照组分别为1.62（0.93-8.50）、98.69（70.0-400.0）、380.60（161.0-2040.0）和0.79（0.37-5.10）。与对照组相比，IGS组的SIRI显著更高（p = 0.036）。IGS组的NLR、PLR和SII也较高，但这种差异未达到统计学显著性水平（分别为p = 0.101、p = 0.600和p = 0.176）。ROC分析显示，SIRI区分IGS的曲线下面积为0.665。SIRI的最佳截断值为0.95，敏感性为64%，特异性为73%。
IGS患者中较高水平的SIRI可能表明亚临床全身炎症与人工晶状体性囊样水肿形成之间存在潜在关联。目前的结果突出了SIRI作为白内障手术后IGS预测因素的潜在效用。
