Nori Priya, Nadeem Naiha, Saraiya Nidhi, Szymczak Wendy, Boland-Reardon Carmel, Kahn Mani
Department of Medicine, Division of Infectious Diseases, Montefiore Medical Centre, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Medicine, Montefiore Wakefield Hospital, Albert Einstein College of Medicine, Bronx, NY, USA.
J Orthop. 2020 Mar 24;21:150-154. doi: 10.1016/j.jor.2020.03.015. eCollection 2020 Sep-Oct.
Group A streptococcal (GAS) infections have high morbidity and mortality due to toxin production and tissue invasion. We reviewed all orthopaedic GAS infections at our medical centre between January 2017 and April 2019. Median age was 56 years. At least 60% had a body mass index (BMI) of ≥30 kg/m. Median Charlson comorbidity score was 3 (range 0-7). Clinical cure at 90 days was achieved in only 62%. All 4 patients with underlying orthopaedic hardware were cured. Toxin-neutralizing antibiotics and intravenous immunoglobulin were underutilized. Our review confirms poor outcomes from GAS orthopaedic infections without optimal management.
A组链球菌（GAS）感染由于毒素产生和组织侵袭而具有较高的发病率和死亡率。我们回顾了2017年1月至2019年4月期间在我们医疗中心发生的所有骨科GAS感染病例。中位年龄为56岁。至少60%的患者体重指数（BMI）≥30kg/m²。查尔森合并症评分中位数为3（范围0-7）。90天时仅有62%实现临床治愈。所有4例有潜在骨科植入物的患者均获治愈。毒素中和抗生素和静脉注射免疫球蛋白未得到充分利用。我们的回顾证实，GAS骨科感染若未得到最佳管理，预后较差。
