Liu Xiangtong, Zhang Jingbo, Wu Jingwei, Xu Xiaolin, Tao Lixin, Sun Yue, Chen Shuo, Han Yumei, Luo Yanxia, Yang Xinghua, Guo Xiuhua
School of Public Health, Capital Medical University, Beijing, People's Republic of China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Mar 19;13:819-834. doi: 10.2147/DMSO.S237550. eCollection 2020.
To determine what metabolic abnormalities develop frequently among metabolically healthy adults over time according to different baseline body mass index (BMI) categories.
A prospective cohort study was performed on 10,805 adults, who were metabolically healthy at the time of the 2008 survey. Participants were divided into four groups: metabolically healthy obese (MHO), metabolically healthy overweight (MHOW), metabolically healthy normal-weight (MHN), and metabolically healthy underweight (MHU). Modified Poisson regression models were used to evaluate the relationship of BMI with the development of metabolic abnormalities. Association rule mining was used to identify the most frequent abnormalities that developed over time.
Compared with the MHN group, the adjusted relative risks of the MHO group were 1.57 (95% CI: 1.09-2.27) and 2.08 (95% CI: 1.59-2.73) for developing elevated fasting glucose and elevated blood pressure, respectively, after adjusting for lifestyle behaviours and dietary factors. At the end of follow-up, 33 (19.1%) MHO subjects and 342 (16.6%) MHOW subjects had elevated blood pressure as the predominant metabolic syndrome component, whereas 236 (9.0%) MHU subjects had elevated plasma glucose. The results were similar after stratification by sex.
MHO and MHOW subjects developed elevated blood pressure most frequently, and MHU subjects developed elevated blood glucose most commonly, regardless of sex.
根据不同的基线体重指数（BMI）类别，确定随着时间推移代谢健康的成年人中经常出现哪些代谢异常。
对10805名成年人进行了一项前瞻性队列研究，这些成年人在2008年调查时代谢健康。参与者被分为四组：代谢健康的肥胖者（MHO）、代谢健康的超重者（MHOW）、代谢健康的正常体重者（MHN）和代谢健康的体重过轻者（MHU）。采用修正的泊松回归模型评估BMI与代谢异常发生之间的关系。使用关联规则挖掘来识别随时间推移最常出现的异常。
与MHN组相比，在调整生活方式行为和饮食因素后，MHO组发生空腹血糖升高和血压升高的校正相对风险分别为1.57（95%CI：1.09 - 2.27）和2.08（95%CI：1.59 - 2.73）。随访结束时，33名（19.1%）MHO受试者和342名（16.6%）MHOW受试者以血压升高作为主要的代谢综合征组分，而236名（9.0%）MHU受试者出现血糖升高。按性别分层后的结果相似。
无论性别如何，MHO和MHOW受试者最常出现血压升高，而MHU受试者最常出现血糖升高。
