Liu Hai-Lin, Zhou Rui-Hao, Luo Li-Li, Yuan Xue, Ye Ling, Luo He-Guo
Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, People's Republic of China.
Department of Pain Management, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
J Pain Res. 2020 Mar 19;13:565-573. doi: 10.2147/JPR.S222767. eCollection 2020.
Although ultrasound-guided transversus abdominis plane block (TAPB) is widely used in multimodal analgesia after cesarean delivery (CD), the complications of TAPB during analgesia after CD have rarely been reported.
A total of 84 cases of CD were randomly assigned to either a ropivacaine group (R group) or ropivacaine + dexamethasone group (RD group) in this double-blind trial. The pain site and pain degree at rest and during activity at 2 h, 6 h, 10 h, 12 h, 14 h, 16 h, 20 h, and 24 h after maternal surgery were recorded. The consumption of opioids at 24h, postoperative nausea, vomiting, exhaustion, and other adverse reactions were recorded.
A total of 80 patients were included in the analysis of results. A total of 19 patients developed ISP, 14 in the R group and 5 in the RD group. The incidence of ISP in the R and RD groups was 35% and 12.5%, respectively. The results described above showed that combining dexamethasone with ropivacaine reduced the incidence of ISP, and the difference was statistically significant (P<0.05). Two groups of women with positive ISP had higher values of opioid consumption than women with negative ISP, but the difference was not significant.
Dexamethasone as an adjuvant for ropivacaine can effectively relieve the ISP of ultrasound-guided TAPB after CD, and can enhance the analgesic effect of ropivacaine.
尽管超声引导下腹横肌平面阻滞(TAPB)在剖宫产术后多模式镇痛中广泛应用,但剖宫产术后镇痛期间TAPB的并发症鲜有报道。
在这项双盲试验中,84例剖宫产患者被随机分为罗哌卡因组(R组)和罗哌卡因+地塞米松组(RD组)。记录产妇术后2小时、6小时、10小时、12小时、14小时、16小时、20小时和24小时静息及活动时的疼痛部位和疼痛程度。记录24小时阿片类药物消耗量、术后恶心、呕吐、疲惫及其他不良反应。
共80例患者纳入结果分析。共有19例患者发生切口痛(ISP),R组14例,RD组5例。R组和RD组ISP发生率分别为35%和12.5%。上述结果表明,地塞米松与罗哌卡因联合使用可降低ISP发生率,差异有统计学意义(P<0.05)。两组ISP阳性的女性阿片类药物消耗量高于ISP阴性的女性,但差异无统计学意义。
地塞米松作为罗哌卡因的辅助药物,可有效缓解剖宫产术后超声引导下TAPB的ISP,并可增强罗哌卡因的镇痛效果。