Stonys Ricardas, Banys Valdas, Vitkus Dalius, Lima-Oliveira Gabriel
Center of Laboratory Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
EJIFCC. 2020 Mar 20;31(1):28-45. eCollection 2020 Mar.
In the daily laboratory practice, there are patients coming to blood collection sites chewing sugar-free gum, considering it irrelevant to laboratory tests. The aim of this study was to evaluate whether a sugar-free chewing gum can interfere with laboratory tests.
We studied 22 healthy volunteers. After a 12-hour overnight fasting, the first blood sample was collected between 8:00 and 8:30 a.m. Then, immediately after the first venous blood collection, the subjects started chewing the gum (declared sugar-free) for 20 min. Subsequent venous blood samples were collected at 1, 2, and 4 hours after chewing the gum. Significant differences between samples were assessed by the Wilcoxon ranked-pairs test.
Among all the results, statistically significant differences ( < 0.05) between basal and × hours after chewing sugar-free gum were observed for the following parameters: cortisol, insulin, C-peptide, triglycerides, uric acid, urea, amylase, alanine aminotransferase, lipase, creatine kinase, total bilirubin, direct bilirubin, phosphate, iron, potassium, thyroid stimulating hormone, red blood cell count, hematocrit, hemoglobin, mean cell volume, red cell distribution width, white blood cell count, lymphocytes, neutrophils, and eosinophils; whereas, coagulation tests were not impacted by chewing sugar-free gum.
We recommend instructing the patients to avoid the use of chewing gum before blood collection for laboratory tests.
在日常实验室操作中，有患者到采血点时嚼着无糖口香糖，认为这与实验室检查无关。本研究的目的是评估无糖口香糖是否会干扰实验室检查。
我们研究了22名健康志愿者。在禁食12小时过夜后，于上午8:00至8:30采集第一份血样。然后，在首次静脉采血后，受试者立即开始嚼口香糖（宣称无糖）20分钟。在嚼口香糖后1小时、2小时和4小时采集后续静脉血样。样本间的显著差异通过Wilcoxon秩和检验进行评估。
在所有结果中，观察到嚼无糖口香糖后与基础值相比，以下参数在统计学上有显著差异（<0.05）：皮质醇、胰岛素、C肽、甘油三酯、尿酸、尿素、淀粉酶、丙氨酸转氨酶、脂肪酶、肌酸激酶、总胆红素、直接胆红素、磷酸盐、铁、钾、促甲状腺激素、红细胞计数、血细胞比容、血红蛋白、平均红细胞体积、红细胞分布宽度、白细胞计数、淋巴细胞、中性粒细胞和嗜酸性粒细胞；而凝血试验不受嚼无糖口香糖的影响。
我们建议告知患者在进行实验室检查采血前避免嚼口香糖。
