Zynat Jazyra, Li Suli, Ma Yanrong, Han Li, Ma Fuhui, Zhang Yuyuan, Xing Bei, Wang Xinling, Guo Yanying
Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, China.
Int J Endocrinol. 2020 Mar 13;2020:6816198. doi: 10.1155/2020/6816198. eCollection 2020.
The interrelation between obesity and autoimmune thyroid diseases is complex and has not been confirmed. The aim of the present study was to observe the relationship between thyroid autoimmunity and obesity, especially abdominal obesity, in a large population.
A total of 2253 residents who had lived in Xinjiang for more than 3 years were enrolled. Serum thyroid hormone concentration, thyroid autoantibodies, lipid parameters, Weight, height, and waist and hip circumference were measured.
The prevalence of thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) positive was 32.1% (21.2% in men and 37% in women, < 0.01). Compared with women, men had significantly higher TG levels, waist circumference, and hip circumference levels ( < 0.01), while women showed higher TSH, TPOAb, and TgAb levels ( < 0.01). The prevalence of overweight and obesity was 71.1% in men and 63.5% in women. Men had a higher prevalence of abdominal obesity than women (56.6% in men and 47.6% in women, < 0.01). TPOAb correlates positively with waist circumference ( = 0.100, < 0.05) in men. Binary logistic analysis showed that TPOAb positivity had increased risks of abdominal obesity in men, and the OR was 1.1044 (95% CI 1.035, 1.151, < 0.05).
Our results indicate that men had higher lipid levels, thicker waist circumference, and higher prevalence of overweight, obesity, and abdominal obesity. Abdominal obesity is a risk factor for TPOAb positivity in men, suggesting that abdominal obesity can enhance the risk of thyroid autoimmunity in men.
肥胖与自身免疫性甲状腺疾病之间的相互关系复杂且尚未得到证实。本研究的目的是在大量人群中观察甲状腺自身免疫与肥胖尤其是腹型肥胖之间的关系。
共纳入2253名在新疆居住超过3年的居民。测量血清甲状腺激素浓度、甲状腺自身抗体、血脂参数、体重、身高以及腰围和臀围。
甲状腺过氧化物酶抗体（TPOAb）和/或甲状腺球蛋白抗体（TgAb）阳性的患病率为32.1%（男性为21.2%，女性为37%，P<0.01）。与女性相比，男性的甘油三酯（TG）水平、腰围和臀围水平显著更高（P<0.01），而女性的促甲状腺激素（TSH）、TPOAb和TgAb水平更高（P<0.01）。男性超重和肥胖的患病率为71.1%，女性为63.5%。男性腹型肥胖的患病率高于女性（男性为56.6%，女性为47.6%，P<0.01）。在男性中，TPOAb与腰围呈正相关（r=0.100，P<0.05）。二元逻辑回归分析显示，TPOAb阳性使男性腹型肥胖的风险增加，比值比（OR）为1.1044（95%置信区间为1.035，1.151，P<0.05）。
我们的结果表明，男性的血脂水平更高、腰围更粗，超重、肥胖和腹型肥胖的患病率更高。腹型肥胖是男性TPOAb阳性的一个危险因素，提示腹型肥胖可增加男性甲状腺自身免疫的风险。
