Shankhwar S N, Mahdi A A, Sharma A V, Pv Kishan
Department of Urology, King George's Medical University, (Formerly Chhatrapati Shahuji Maharaj Medical University), Uttar Pradesh, Lucknow 226003, India.
Department of Biochemistry, King George's Medical University, (Formerly Chhatrapati Shahuji Maharaj Medical University), Uttar Pradesh, Lucknow 226003, India.
Evid Based Complement Alternat Med. 2020 Mar 11;2020:4598217. doi: 10.1155/2020/4598217. eCollection 2020.
The present study aimed to assess the effects of Nano Leo, a prosexual nutrient formulation, on libido, erection, and orgasm in patients with erectile dysfunction (ED).
This was a prospective, single-center, phase IV efficacy study. Patients received two capsules for 7 days and thereafter one capsule through 90 days. Main outcome measures: primary endpoint was change in erectile function assessed using the International Index of Erectile Function (IIEF) questionnaire. Secondary endpoints included improvement in testosterone levels, FSH, LH, and prolactin levels; seminal parameters; and overall quality of life (QoL).
Our study included 99 men (mean age 32.2 ± 4.71 years). Mean erectile function domain score increased from 18.9 ± 5.67 at baseline to 23.7 ± 4.01 on day 90 ( < 0.001). Similar improvements were observed in orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction domains of IIEF score which was seen as early as day 30. Improved IIEF corroborated with improvement in all QoL domains. From baseline to day 90, treatment with Nano Leo increased testosterone levels (5.04 ± 2.22 vs. 5.57 ± 1.53 ng/mL, < 0.001). Similar improvements were observed in orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction domains of IIEF score which was seen as early as day 30. Improved IIEF corroborated with improvement in all QoL domains. From baseline to day 90, treatment with Nano Leo increased testosterone levels (5.04 ± 2.22 vs. 5.57 ± 1.53 ng/mL.
Nano Leo showed improved libido, erection, and orgasm as evaluated by IIEF and QoL and was well tolerated. Therefore, Nano Leo could be an effective and safe pronutrient supplement in managing ED.
本研究旨在评估一种促进性功能的营养制剂Nano Leo对勃起功能障碍（ED）患者的性欲、勃起和性高潮的影响。
这是一项前瞻性、单中心、IV期疗效研究。患者服用两粒胶囊，持续7天，之后90天每天服用一粒胶囊。主要结局指标：主要终点是使用国际勃起功能指数（IIEF）问卷评估的勃起功能变化。次要终点包括睾酮水平、促卵泡激素（FSH）、促黄体生成素（LH）和催乳素水平的改善；精液参数；以及总体生活质量（QoL）。
我们的研究纳入了99名男性（平均年龄32.2±4.71岁）。勃起功能领域的平均得分从基线时的18.9±5.67提高到第90天时的23.7±4.01（P<0.001）。IIEF评分的性高潮功能、性欲、性交满意度和总体满意度领域也观察到类似的改善，最早在第30天就出现了。IIEF的改善与所有生活质量领域的改善相一致。从基线到第90天，Nano Leo治疗使睾酮水平升高（5.04±2.22 vs. 5.57±1.53 ng/mL，P<0.001）。IIEF评分的性高潮功能、性欲、性交满意度和总体满意度领域也观察到类似的改善，最早在第30天就出现了。IIEF的改善与所有生活质量领域的改善相一致。从基线到第90天，Nano Leo治疗使睾酮水平升高（5.04±2.22 vs. 5.57±1.53 ng/mL）。
根据IIEF和QoL评估，Nano Leo显示出性欲、勃起和性高潮的改善，且耐受性良好。因此，Nano Leo可能是一种有效且安全的前营养素补充剂，可用于治疗ED。
