Corman B, Michel J B
Départment de Biologie, C.E.N. Saclay, Gif-sur-Yvette, France.
J Hypertens Suppl. 1988 Dec;6(3):S65-8.
Acute or chronic inhibition of angiotensin converting enzyme (ACE) activity in normotensive rats may increase, decrease or cause no change in renal blood flow. Since renal blood flow and the glomerular filtration rate are highly dependent on protein intake, we investigated the question of whether the reported differences in the renal effects of ACE inhibition can be explained by the level of food intake. Glomerular filtration and arterial pressure were measured in conscious, chronically catheterized rats, which were either fed or fasted for 24 h on the day of experiment. In the control group, the glomerular filtration rate was 45% higher in fed than in fasted rats, while blood pressure and plasma renin concentration were unchanged. In experimental animals, given daily 1-mg/kg doses of the ACE inhibitor perindopril, the glomerular filtration rate was the same in both fed and fasted animals and comparable to the values of fasted control animals. Mean blood pressure was reduced from 113 to 91 mmHg by perindopril. It is concluded that chronic ACE inhibition prevents postprandial hyperfiltration and decreases the blood pressure of fed or fasted rats by 20 mmHg, but does not affect renal function in fasted rats.
正常血压大鼠体内血管紧张素转换酶（ACE）活性的急性或慢性抑制可能会使肾血流量增加、减少或无变化。由于肾血流量和肾小球滤过率高度依赖蛋白质摄入量，我们研究了一个问题，即报道的ACE抑制对肾脏影响的差异是否可以用食物摄入量来解释。在实验当天，对清醒的、长期插管的大鼠进行肾小球滤过和动脉血压测量，这些大鼠要么喂食24小时，要么禁食24小时。在对照组中，喂食大鼠的肾小球滤过率比禁食大鼠高45%，而血压和血浆肾素浓度没有变化。在实验动物中，每天给予1毫克/千克剂量的ACE抑制剂培哚普利，喂食和禁食动物的肾小球滤过率相同，且与禁食对照动物的值相当。培哚普利使平均血压从113毫米汞柱降至91毫米汞柱。结论是，慢性ACE抑制可防止餐后超滤，并使喂食或禁食大鼠的血压降低20毫米汞柱，但不影响禁食大鼠的肾功能。
