从头到脚的磷尿性间叶肿瘤：影像学表现及放射科医生在诊断肿瘤性骨软化症中的作用
Phosphaturic Mesenchymal Tumors from Head to Toe: Imaging Findings and Role of the Radiologist in Diagnosing Tumor-Induced Osteomalacia.
作者信息
Kawthalkar Ameya S, Janu Amit K, Deshpande Mrunmayee S, Gala Kunal B, Gulia Ashish, Puri Ajay
机构信息
1Department of Radiology, Grant Medical College and Sir JJ Hospital, Mumbai, India.
2Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, India.
出版信息
Indian J Orthop. 2020 Jan 13;54(2):215-223. doi: 10.1007/s43465-019-00005-5. eCollection 2020 Apr.
BACKGROUND
This study aimed at evaluating the imaging findings of phosphaturic mesenchymal tumors and tumor-induced osteomalacia and assess the clinical and biochemical profiles of patients with tumor-induced osteomalacia.
MATERIALS AND METHODS
Imaging findings in six patients with tumor-induced osteomalacia and histopathologically proven phosphaturic mesenchymal tumors were evaluated. Clinical and biochemical profiles of these patients were also assessed.
RESULTS
Along with having a characteristic biochemical profile, patients with phosphaturic mesenchymal tumors also have certain imaging findings which can aid in the diagnosis such as increased uptake on DOTA PET-CT and homogeneous post-contrast enhancement on CT and MRI.
CONCLUSION
Patients with tumor-induced osteomalacia have characteristic symptoms, imaging and biochemical profiles. For radiologists, raising the suspicion of a phosphaturic mesenchymal tumor in patients with refractory hypophosphatemic osteomalacia as well as localizing the tumor on imaging is crucial, as complete excision of the tumor leads to resolution of the osteomalacia and the patient's clinical symptoms.
背景
本研究旨在评估磷尿性间叶肿瘤及肿瘤诱导性骨软化症的影像学表现，并评估肿瘤诱导性骨软化症患者的临床及生化特征。
材料与方法
对6例经组织病理学证实为磷尿性间叶肿瘤的肿瘤诱导性骨软化症患者的影像学表现进行评估。同时评估这些患者的临床及生化特征。
结果
除具有特征性的生化特征外，磷尿性间叶肿瘤患者还具有某些有助于诊断的影像学表现，如DOTA PET-CT上摄取增加以及CT和MRI上增强后均匀强化。
结论
肿瘤诱导性骨软化症患者具有特征性的症状、影像学及生化特征。对于放射科医生而言，提高对难治性低磷性骨软化症患者磷尿性间叶肿瘤的怀疑并在影像学上定位肿瘤至关重要，因为肿瘤的完全切除可导致骨软化症及患者临床症状的缓解。
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