Department of Medicine, Roger Williams Medical Center, Providence, RI, USA.
University of Massachusetts Chan Medical School, Worcester, MA, USA.
Skeletal Radiol. 2024 May;53(5):995-1002. doi: 10.1007/s00256-023-04462-w. Epub 2023 Oct 4.
Phosphaturic mesenchymal tumors are rare, usually benign neoplasms that occur in the soft tissue or bone and are the cause of nearly all cases of tumor-induced osteomalacia. Tumor-induced osteomalacia due to phosphaturic mesenchymal tumor is a challenging diagnosis to make-patients present with variable clinical and radiologic findings and the culprit neoplasm is often small and can occur anywhere head to toe. We present two cases of phosphaturic mesenchymal tumor in the scapular body and plantar foot. In both cases, the patient endured years of debilitating symptoms before a tissue diagnosis was eventually reached. Descriptions of clinical presentation, laboratory workup, surgical resection, and imaging characteristics, with a focus on CT, MRI, and functional imaging, are provided to assist with the diagnosis and management of this rare entity. A brief review of current literature and discussion of the differential diagnoses of phosphaturic mesenchymal tumor is also provided.
磷酸尿基质肿瘤是罕见的，通常为良性肿瘤，发生于软组织或骨骼，是导致几乎所有肿瘤性骨软化症的原因。磷酸尿基质肿瘤引起的肿瘤性骨软化症的诊断具有挑战性——患者表现出不同的临床和影像学表现，且致病肿瘤通常较小，可发生在从头到脚的任何部位。我们报告了两例肩胛体和足底的磷酸尿基质肿瘤病例。在这两种情况下，患者在最终获得组织诊断之前都经历了数年的衰弱症状。提供了对临床表现、实验室检查、手术切除和影像学特征的描述，重点是 CT、MRI 和功能成像，以帮助诊断和管理这种罕见实体。还简要回顾了当前的文献，并讨论了磷酸尿基质肿瘤的鉴别诊断。
