Simmons D J, Daum W J, Calhoun J H
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
J Orthop Trauma. 1988;2(3):245-9. doi: 10.1097/00005131-198802030-00012.
The effects of each of the surgical stages involved in compression plating on the development of cortical thinning and porosity were assessed in the intact midshaft, stress-shielded femoral segments of adult mongrel dogs 6 months postoperatively. The data were evaluated in terms of a postsurgical tetracycline-based measure of remodeling and terminal 85Sr clearance (SrC) values for the plated segments of bone. Drilling had no effect on any parameter. Screw application was associated with minimal cortical thinning (p less than 0.05), while plate fixation clearly promoted thinning (p less than 0.01) and porosity (p less than 0.05). The percentage of labeled osteons, a measure of remodeling activity, increased only after plate fixation (p less than 0.05), and the labeling patterns suggested that most osteons had formed during the first 4 postsurgical months. That none of these changes were correlated with the 6-month SrC values suggests that the development of plate-induced osteopenia involves disparate histomorphometric time constants, rather than lack of any association.
在成年杂种犬完整的股骨干中段、术后6个月应力屏蔽的股骨节段中，评估加压钢板固定术中每个手术阶段对皮质变薄和孔隙率发展的影响。根据术后基于四环素的重塑测量和钢板固定骨段的终末85Sr清除率（SrC）值对数据进行评估。钻孔对任何参数均无影响。拧入螺钉与最小程度的皮质变薄相关（p<0.05），而钢板固定明显促进了皮质变薄（p<0.01）和孔隙率增加（p<0.05）。作为重塑活性指标的标记骨单位百分比仅在钢板固定后增加（p<0.05），且标记模式表明大多数骨单位在术后的前4个月形成。这些变化均与6个月时的SrC值无关，这表明钢板诱导的骨质减少的发展涉及不同的组织形态计量学时间常数，而非缺乏任何关联。
