实验性暴露于西式饮食会损害海马体依赖的食欲控制。
Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet.
作者信息
Stevenson Richard J, Francis Heather M, Attuquayefio Tuki, Gupta Dolly, Yeomans Martin R, Oaten Megan J, Davidson Terry
机构信息
Department of Psychology, Macquarie University, Sydney, New South Wales 2109, Australia.
Department of Psychiatry, Yale University, New Haven, CT, USA.
出版信息
R Soc Open Sci. 2020 Feb 19;7(2):191338. doi: 10.1098/rsos.191338. eCollection 2020 Feb.
Animals fed a Western-style diet (WS-diet) demonstrate rapid impairments in hippocampal function and poorer appetitive control. We examined if this also occurs in humans. One-hundred and ten healthy lean adults were randomized to either a one-week WS-diet intervention or a habitual-diet control group. Measures of hippocampal-dependent learning and memory (HDLM) and of appetitive control were obtained pre- and post-intervention. HDLM was retested at three-week follow-up. Relative to controls, HDLM performance declined in the WS-diet group ( = 0.43), but was not different at follow-up. Appetitive control also declined in the WS-diet group ( = 0.47) and this was strongly correlated with HDLM decline ( = 1.01). These findings demonstrate that a WS-diet can rapidly impair appetitive control in humans-an effect that could promote overeating in consumers of a WS-diet. The study also suggests a functional role for the hippocampus in appetitive control and provides new evidence for the adverse neurocognitive effects of a WS-diet.
食用西式饮食（WS饮食）的动物在海马体功能方面会迅速出现损伤，且食欲控制能力较差。我们研究了这种情况是否也会在人类身上发生。110名健康的瘦成年人被随机分为两组，一组进行为期一周的WS饮食干预，另一组作为习惯饮食对照组。在干预前后分别获取了海马体依赖学习与记忆（HDLM）以及食欲控制的测量数据。在三周随访时对HDLM进行了重新测试。与对照组相比，WS饮食组的HDLM表现下降了（ = 0.43），但在随访时并无差异。WS饮食组的食欲控制也下降了（ = 0.47），且这与HDLM下降密切相关（ = 1.01）。这些发现表明，WS饮食会迅速损害人类的食欲控制——这种效应可能会促使食用WS饮食的人暴饮暴食。该研究还表明海马体在食欲控制中具有功能性作用，并为WS饮食的不良神经认知效应提供了新证据。
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