Minutello J S, Dimayuga R G, Carter J
Department of Periodontics, University of Texas Health Science Center San Antonio.
J Periodontol. 1988 Dec;59(12):848-51. doi: 10.1902/jop.1988.59.12.848.
WITH THE MORE FREQUENT USE of antibiotics as adjuncts to periodontal therapy today, it is imperative that dental clinicians be aware of adverse reactions to these drugs, regardless of their reported incidence. It is the purpose of this case report to present and describe a rare adverse reaction to tetracycline hydrochloride called pseudotumor cerebri or benign intracranial hypertension. It is manifested by an abnormal increase in intracranial pressure and papilledema in a patient with an otherwise normal neuroradiologic condition. Although severe headache appears to be the most bothersome acute symptom, the more important long-term side effect is visual loss caused by the papilledema. Treatment should be directed towards discontinuation of the drug therapy, and immediate referral to a physician for a neuro-ophthalmic evaluation.
随着如今抗生素作为牙周治疗辅助药物的使用愈发频繁，牙科临床医生必须了解这些药物的不良反应，无论其报告的发生率如何。本病例报告的目的是呈现并描述一种罕见的对盐酸四环素的不良反应，称为假性脑瘤或良性颅内高压。它表现为在神经放射学状况正常的患者中颅内压异常升高和视乳头水肿。尽管严重头痛似乎是最困扰人的急性症状，但更重要的长期副作用是视乳头水肿导致的视力丧失。治疗应针对停止药物治疗，并立即转诊给医生进行神经眼科评估。
