Walters B N, Gubbay S S
Br Med J (Clin Res Ed). 1981 Jan 3;282(6257):19-20. doi: 10.1136/bmj.282.6257.19.
Benign intracranial hypertension occurred in four young women taking tetracycline for acne; two were also taking vitamin A. In a fifth case a 14-year-old boy developed papilloedema after taking a short course of tetracycline for bronchitis. All symptoms disappeared soon after stopping the drugs, though in two cases the papilloedema persisted for many months. Benign intracranial hypertension should be sought in any young woman complaining of headache during treatment with tetracycline. Moreover, young women given vitamin A and tetracycline in combination for acne may be at special risk and should be kept under surveillance.
四名年轻女性因治疗痤疮服用四环素后出现良性颅内高压；其中两名还服用了维生素A。第五例中，一名14岁男孩因支气管炎短期服用四环素后出现视乳头水肿。停药后所有症状很快消失，不过有两例视乳头水肿持续了数月。在用四环素治疗期间，任何主诉头痛的年轻女性都应排查是否患有良性颅内高压。此外，联合服用维生素A和四环素治疗痤疮的年轻女性可能面临特殊风险，应接受监测。
