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本文引用的文献

1
Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27.白细胞介素-12细胞因子家族对自然杀伤细胞激活及效应功能的调控：以白细胞介素-27为例
Front Immunol. 2017 Jan 19;8:25. doi: 10.3389/fimmu.2017.00025. eCollection 2017.
2
Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.脂肪组织与中枢神经系统通过分泌因子进行的秘密对话——神经退行性研究中的一个新兴前沿领域。
J Neuroinflammation. 2016 Mar 24;13(1):67. doi: 10.1186/s12974-016-0530-x.
3
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.硫辛酸：其抗氧化和抗炎作用及临床应用
Curr Top Med Chem. 2015;15(5):458-83. doi: 10.2174/1568026615666150114161358.
4
The M1 and M2 paradigm of macrophage activation: time for reassessment.巨噬细胞活化的M1和M2范式：是时候重新评估了。
F1000Prime Rep. 2014 Mar 3;6:13. doi: 10.12703/P6-13. eCollection 2014.
5
The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health.天然和合成脂肪酸对膜结构、微区组织、细胞功能及人类健康的影响。
Biochim Biophys Acta. 2014 Jun;1838(6):1518-28. doi: 10.1016/j.bbamem.2013.12.021. Epub 2014 Jan 3.
6
Free fatty acid receptors and their role in regulation of energy metabolism.游离脂肪酸受体及其在能量代谢调节中的作用。
Rev Physiol Biochem Pharmacol. 2013;164:77-116. doi: 10.1007/112_2013_13.
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8
Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.转录因子复合物 AP-1 介导肺炎衣原体感染引发的炎症反应。
Cell Microbiol. 2013 May;15(5):779-94. doi: 10.1111/cmi.12071. Epub 2012 Dec 16.
9
The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials.长期补充共轭亚油酸 (CLA) 对超重和肥胖个体身体成分的影响：随机临床试验的系统评价和荟萃分析。
Eur J Nutr. 2012 Mar;51(2):127-34. doi: 10.1007/s00394-011-0253-9. Epub 2011 Oct 12.
10
HIV infection, inflammation, immunosenescence, and aging.HIV 感染、炎症、免疫衰老和衰老。
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共轭亚油酸与α-硫辛酸通过二者间的分子相互作用产生相加性抗炎作用。

Additive anti-inflammation by a combination of conjugated linoleic acid and α-lipoic acid through molecular interaction between both compounds.

作者信息

Lee Ki-June, Ko Yoon-Joo, Kang Sang-Kee, Kim Whee-Soo, Cho Chong-Su, Choi Yun-Jaie

机构信息

1Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826 Republic of Korea.

2National Center for Inter-University Research Facilities, Seoul National University, Seoul, 08826 Republic of Korea.

出版信息

Food Sci Biotechnol. 2019 Oct 15;29(3):419-429. doi: 10.1007/s10068-019-00677-7. eCollection 2020 Mar.

DOI:10.1007/s10068-019-00677-7
PMID:32257526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7105553/
Abstract

Alpha lipoic acid (LA) and conjugated linoleic acid (CLA) have been well-documented on a variety of functional effects in health foods. The main purpose of this study was focused on the additive anti-inflammatory activity of the combination of LA and CLA in vitro. Raw 264.7 cells induced by lipopolysaccharide were treated with LA and CLA individually or in combination at a variety of concentration ranges. Co-treating 25 μM of LA and 25 μM of CLA significantly inhibited pro-inflammatory cytokines compared to the same concentration of single LA- or CLA-treated group. The molecular mechanism of anti-inflammation by a combination of these compounds was attributed to extracellular signal-regulated kinase-1 (ERK1) and peroxisome proliferator-activated receptor gamma (PPARγ). Also, the molecular interaction between both compounds was confirmed by NMR. Our findings suggested that the combination of CLA and LA showed potential additive effect on anti-inflammation through the molecular interaction of both compounds.

摘要

α-硫辛酸（LA）和共轭亚油酸（CLA）在保健食品中的多种功能作用已得到充分记载。本研究的主要目的聚焦于LA和CLA组合在体外的附加抗炎活性。用脂多糖诱导的Raw 264.7细胞分别或联合使用不同浓度范围的LA和CLA进行处理。与相同浓度的单一LA或CLA处理组相比，联合使用25μM的LA和25μM的CLA可显著抑制促炎细胞因子。这些化合物组合的抗炎分子机制归因于细胞外信号调节激酶-1（ERK1）和过氧化物酶体增殖物激活受体γ（PPARγ）。此外，通过核磁共振证实了这两种化合物之间的分子相互作用。我们的研究结果表明，CLA和LA的组合通过两种化合物的分子相互作用显示出潜在的附加抗炎作用。