Ibarguren Maitane, López David J, Escribá Pablo V
Laboratory of Molecular Cell Biomedicine, University of the Balearic Islands, Palma de Mallorca, Spain; Lipopharma Therapeutics S.L., Palma de Mallorca, Spain.
Laboratory of Molecular Cell Biomedicine, University of the Balearic Islands, Palma de Mallorca, Spain.
Biochim Biophys Acta. 2014 Jun;1838(6):1518-28. doi: 10.1016/j.bbamem.2013.12.021. Epub 2014 Jan 3.
This review deals with the effects of synthetic and natural fatty acids on the biophysical properties of membranes, and on their implication on cell function. Natural fatty acids are constituents of more complex lipids, like triacylglycerides or phospholipids, which are used by cells to store and obtain energy, as well as for structural purposes. Accordingly, natural and synthetic fatty acids may modify the structure of the lipid membrane, altering its microdomain organization and other physical properties, and provoking changes in cell signaling. Therefore, by modulating fatty acids it is possible to regulate the structure of the membrane, influencing the cell processes that are reliant on this structure and potentially reverting pathological cell dysfunctions that may provoke cancer, diabetes, hypertension, Alzheimer's and Parkinson's disease. The so-called Membrane Lipid Therapy offers a strategy to regulate the membrane composition through drug administration, potentially reverting pathological processes by re-adapting cell membrane structure. Certain fatty acids and their synthetic derivatives are described here that may potentially be used in such therapies, where the cell membrane itself can be considered as a target to combat disease. This article is part of a Special Issue entitled: Membrane Structure and Function: Relevance in the Cell's Physiology, Pathology and Therapy.
本综述探讨了合成脂肪酸和天然脂肪酸对膜生物物理性质的影响，以及它们对细胞功能的影响。天然脂肪酸是更复杂脂质（如甘油三酯或磷脂）的组成成分，细胞利用这些脂质储存和获取能量，以及用于结构目的。因此，天然脂肪酸和合成脂肪酸可能会改变脂质膜的结构，改变其微区组织和其他物理性质，并引发细胞信号传导的变化。因此，通过调节脂肪酸，可以调节膜的结构，影响依赖于该结构的细胞过程，并有可能逆转可能引发癌症、糖尿病、高血压、阿尔茨海默病和帕金森病的病理性细胞功能障碍。所谓的膜脂质疗法提供了一种通过药物给药来调节膜组成的策略，有可能通过重新调整细胞膜结构来逆转病理过程。本文描述了某些脂肪酸及其合成衍生物，它们可能潜在地用于此类疗法，其中细胞膜本身可被视为对抗疾病的靶点。本文是名为：膜结构与功能：在细胞生理学、病理学和治疗中的相关性的特刊的一部分。
