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青少年原发性肾淋巴瘤:一例报告

Teenager with a Primary Renal Lymphoma: A Case Report.

作者信息

Arriola-Montenegro Liliana, Palacios-Revilla Cecilia D, Cateriano-Alberdi Maria Paula, Valdivia-Vega Renzo P, Arriola-Montenegro Jose

机构信息

Internal Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, PER.

Nephrology, Hospital Nacional Edgardo Rebagliati Martins, Lima, PER.

出版信息

Cureus. 2020 Mar 4;12(3):e7181. doi: 10.7759/cureus.7181.

Abstract

We report a case of an 18-year-old male patient who was diagnosed with primary renal lymphoma (PRL) through biopsy findings and imaging studies. The patient presented with clinical manifestations of distal renal tubular acidosis including polyuria, polydipsia, lower limb weakness, involuntary weight loss, asthenia and dyspnea. No personal background or relevant medical history was reported. A kidney biopsy showed high grade immature B-cell lymphoproliferative process (Non-Hodgkin's Lymphoma) with a Ki67 value greater than 90%. Complementary studies excluded primary lymphoid migration sites, which confirmed the diagnosis of PRL. The oncology unit initiated treatment with a combination of medications due to lack of protocols for the specific treatment. Besides the fact that this condition is rare, it also shows a unique symptoms presentation and non-typical findings in imaging methods. Also, it is important to underline the fact that the treatment is not yet specified for such type of cancer and different combinations are needed to control the disease.

摘要

我们报告了一例18岁男性患者,通过活检结果和影像学检查被诊断为原发性肾淋巴瘤(PRL)。该患者表现出远端肾小管酸中毒的临床表现,包括多尿、烦渴、下肢无力、体重不由自主减轻、乏力和呼吸困难。未报告个人背景或相关病史。肾脏活检显示高级别不成熟B细胞淋巴增殖过程(非霍奇金淋巴瘤),Ki67值大于90%。补充研究排除了原发性淋巴迁移部位,从而确诊为PRL。由于缺乏针对该特定治疗的方案,肿瘤学部门开始联合用药治疗。除了这种情况罕见之外,它还表现出独特的症状表现和影像学方法中的非典型发现。同样重要的是要强调,对于这种类型的癌症,治疗方法尚未明确,需要不同的联合治疗来控制疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/7124830/15348951b96c/cureus-0012-00000007181-i01.jpg

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