Agrawala P, Ritschel W A
Division of Pharmaceutics and Drug Delivery Systems, College of Pharmacy, University of Cincinnati Medical Center, OH 45267-0004.
J Pharm Sci. 1988 Sep;77(9):776-8. doi: 10.1002/jps.2600770912.
The effect of 1-dodecylhexahydro-2H-azepine-2-one (Azone; laurocapran; 1) on the permeation of verapamil hydrochloride (2) through rat skin was studied. Compound 1 was used in various concentrations in the donor phase. The permeation of the drug increased significantly in the presence of 1 and the enhancement in permeation was dependent on the concentration of 1. A comparison of the enhancing effect of 3% 1 on permeation of 2 through rat, hairless mouse, and human cadaver skin was made. Compound 1 altered the permeability of hairless mouse skin significantly, whereas the effect on rat and human skin was comparable and not very drastic.
研究了1-十二烷基六氢-2H-氮杂卓-2-酮（氮酮；月桂氮卓酮；1）对盐酸维拉帕米（2）透过大鼠皮肤的影响。化合物1在供体相中以不同浓度使用。在存在1的情况下，药物的渗透显著增加，且渗透增强取决于1的浓度。比较了3%的1对2透过大鼠、无毛小鼠和人体尸体皮肤的增强作用。化合物1显著改变了无毛小鼠皮肤的渗透性，而对大鼠和人体皮肤的影响相当且不太显著。
