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唑来膦酸治疗妊娠相关股骨头坏死:一例报告。

Zoledronic acid for the treatment of pregnancy-associated femoral head necrosis: A case report.

作者信息

Musacchio Estella, Sartori Leonardo

机构信息

Department of Medicine DIMED, Clinica Medica 1, University of Padova, via Giustiniani 2, 35128 Padova, Italy.

出版信息

Case Rep Womens Health. 2020 Mar 19;26:e00190. doi: 10.1016/j.crwh.2020.e00190. eCollection 2020 Apr.

DOI:10.1016/j.crwh.2020.e00190
PMID:32257828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7109417/
Abstract

INTRODUCTION

The management of pregnancy-associated femoral necrosis is controversial. Conservative management may eventually lead to hip replacement.

CASE

A 40-year-old woman developed necrosis of the left hip during her first pregnancy. Treatment with zoledronic acid three months after delivery resulted in rapid reduction of the necrotic area. The patient's second pregnancy shortly afterwards had no complications. A magnetic resonance scan three years later documented complete resolution.

CONCLUSION

Femoral head necrosis should be suspected in the differential diagnosis of pain in pregnancy. Zoledronic acid given in the early stages prevented progression to hip arthritis in this case.

摘要

引言

妊娠相关股骨头坏死的治疗存在争议。保守治疗最终可能导致髋关节置换。

病例

一名40岁女性在首次怀孕期间出现左髋坏死。产后三个月使用唑来膦酸治疗,坏死面积迅速缩小。此后不久患者再次怀孕,未出现并发症。三年后的磁共振扫描显示完全恢复。

结论

在妊娠疼痛的鉴别诊断中应怀疑股骨头坏死。在本例中,早期给予唑来膦酸可防止发展为髋关节炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/7109417/b7cfd277a67e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/7109417/b7cfd277a67e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/7109417/b7cfd277a67e/gr1.jpg

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本文引用的文献

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The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head.2019 年版股骨头坏死的协会研究循环性骨坏死分期系统。
J Arthroplasty. 2020 Apr;35(4):933-940. doi: 10.1016/j.arth.2019.11.029. Epub 2019 Nov 27.
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Unusual indication of Cell therapy for hip osteonecrosis after pregnancy.细胞疗法在产后髋部骨坏死中的不寻常应用。
SICOT J. 2018;4:46. doi: 10.1051/sicotj/2018044. Epub 2018 Nov 5.
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Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study.
妊娠及暴露于双膦酸盐后新生儿结局:病例对照研究。
Osteoporos Int. 2019 Jan;30(1):221-229. doi: 10.1007/s00198-018-4672-9. Epub 2018 Aug 31.
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Hip osteonecrosis and pregnancy in healthy women.健康女性的髋关节骨坏死与妊娠
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Non traumatic osteonecrosis of the femoral head is associated with low bone mass.非创伤性股骨头坏死与低骨量有关。
Bone. 2018 Feb;107:88-92. doi: 10.1016/j.bone.2017.11.005. Epub 2017 Nov 14.
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Transient osteoporosis of the hip: review of the literature.髋关节一过性骨质疏松症:文献复习。
Osteoporos Int. 2017 Jun;28(6):1805-1816. doi: 10.1007/s00198-017-3952-0. Epub 2017 Mar 17.
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Aseptic necrosis of the femoral head after pregnancy: a case report.妊娠后股骨头无菌性坏死:一例报告
Pan Afr Med J. 2016 Jul 7;24:195. doi: 10.11604/pamj.2016.24.195.7325. eCollection 2016.
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Bilateral Osteonecrosis of the Femoral Head During Pregnancy Following Two Corticosteroid Injections: A Case Report and Review of the Literature.两次注射皮质类固醇后孕期双侧股骨头缺血性坏死:一例报告并文献复习
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9
Does Zoledronate Prevent Femoral Head Collapse from Osteonecrosis? A Prospective, Randomized, Open-Label, Multicenter Study.唑来膦酸盐能否预防股骨头坏死导致的股骨头塌陷?一项前瞻性、随机、开放标签、多中心研究。
J Bone Joint Surg Am. 2015 Jul 15;97(14):1142-8. doi: 10.2106/JBJS.N.01157.
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Osteonecrosis of the femoral head: diagnosis and classification systems.股骨头坏死:诊断与分类系统
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