Choy Jeremy T, Eisenberg Michael L
Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA, USA.
Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Transl Androl Urol. 2020 Mar;9(Suppl 2):S239-S243. doi: 10.21037/tau.2019.08.35.
There is increasing evidence that male infertility may be a harbinger of comorbid medical illness. Existing studies have shed light on associations between infertility and the prevalence of cardiovascular, metabolic, and oncologic disease, along with rates of hospitalization and overall mortality. Although theorized mechanisms include genetic, developmental, and behavioral precipitants, the exact nature of these associations remains unclear and warrants further investigation.
越来越多的证据表明，男性不育可能是合并内科疾病的先兆。现有研究揭示了不育与心血管疾病、代谢疾病和肿瘤疾病的患病率之间的关联，以及住院率和总体死亡率。尽管理论上的机制包括遗传、发育和行为诱因，但这些关联的确切性质仍不清楚，值得进一步研究。
